Search Results - "proteins"

Inhibiting protein-protein interactions part 1 of 2 /

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Inhibiting protein-protein interactions part 2 of 2 /

Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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Protein-protein interaction networks

Table of Contents: “…Contents: General features of networks -- Creative network nodes -- Overview of cellular networks -- Definition and databases of protein-protein interaction networks -- Main methods to identify protein interaction data and their quality -- Small worldness, hubs (date and party hubs, rich clubs) and modules of protein-protein interaction networks -- Change of modular overlaps as an efficient method of adaptation.…”
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Inhibiting protein-protein interactions part 1 of 2 /

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Inhibiting protein-protein interactions part 2 of 2 /

Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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Series

Protein-protein interaction networks

Table of Contents: “…Contents: General features of networks -- Creative network nodes -- Overview of cellular networks -- Definition and databases of protein-protein interaction networks -- Main methods to identify protein interaction data and their quality -- Small worldness, hubs (date and party hubs, rich clubs) and modules of protein-protein interaction networks -- Change of modular overlaps as an efficient method of adaptation.…”
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Series

Protein-protein interaction networks

Table of Contents: “…Contents: General features of networks -- Creative network nodes -- Overview of cellular networks -- Definition and databases of protein-protein interaction networks -- Main methods to identify protein interaction data and their quality -- Small worldness, hubs (date and party hubs, rich clubs) and modules of protein-protein interaction networks -- Change of modular overlaps as an efficient method of adaptation.…”
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Inhibiting protein-protein interactions part 1 of 2 /

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Inhibiting protein-protein interactions part 2 of 2 /

Table of Contents: “…Contents: A different view of druggability -- Five propositions about the druggability of PPI targets -- Protein-ligand binding energy -- Ligand efficiency and drug-target binding -- ADME & druglikeness considerations -- Conventional view of druglikeness -- Druggability and chemical space -- Targeting low druggability PPI -- Macrocycles -- Covalent inhibitors -- Foldamers.…”
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Fuzzy protein theory for disordered proteins

Table of Contents: “…Contents: Intelligent decision-making mechanisms -- Structural disorder is maintained in protein assemblies -- Mechanisms and biological consequences of fuzziness -- Conformational diversity and context-dependence -- Fuzziness in cell differentiation and transcription factor evolution -- Material state and regulation of higher-order assemblies.…”
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Protein phosphorylation and the control of protein synthesis

Table of Contents: “…Contents: Protein synthesis -- Key step in gene expression that must be tightly controlled -- Signaling pathways regulate phosphorylation and activity of translation factor proteins -- Important in regulation of cell growth and division -- Defective control linked to human diseases such as cancer and cardiac hypertrophy.…”
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Fuzzy protein theory for disordered proteins

Table of Contents: “…Contents: Intelligent decision-making mechanisms -- Structural disorder is maintained in protein assemblies -- Mechanisms and biological consequences of fuzziness -- Conformational diversity and context-dependence -- Fuzziness in cell differentiation and transcription factor evolution -- Material state and regulation of higher-order assemblies.…”
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Protein phosphorylation and the control of protein synthesis

Table of Contents: “…Contents: Protein synthesis -- Key step in gene expression that must be tightly controlled -- Signaling pathways regulate phosphorylation and activity of translation factor proteins -- Important in regulation of cell growth and division -- Defective control linked to human diseases such as cancer and cardiac hypertrophy.…”
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Protein phosphorylation and the control of protein synthesis

Table of Contents: “…Contents: Protein synthesis -- Key step in gene expression that must be tightly controlled -- Signaling pathways regulate phosphorylation and activity of translation factor proteins -- Important in regulation of cell growth and division -- Defective control linked to human diseases such as cancer and cardiac hypertrophy.…”
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Fuzzy protein theory for disordered proteins

Table of Contents: “…Contents: Intelligent decision-making mechanisms -- Structural disorder is maintained in protein assemblies -- Mechanisms and biological consequences of fuzziness -- Conformational diversity and context-dependence -- Fuzziness in cell differentiation and transcription factor evolution -- Material state and regulation of higher-order assemblies.…”
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Protein degradation

Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Protein crystallography

Table of Contents: “…Contents: Protein crystallography -- Protein crystallization methods -- Crystal symmetry -- X-ray intensity data collection -- Electron density equation -- The Patterson function -- Multiple isomorphous replacement phasing -- Fitting the electron density with a model -- Refinement of the model -- Estimating quality of the model.…”
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Protein folding

Table of Contents: “…Contents: Introduction to principles of protein structure -- The basic facts about protein folding -- Cooperativity of protein structure formation -- Necessary and sufficient conditions for protein sequences to fold -- Concept of energy gap -- Protein folding kinetics -- Intermediates and transition state ensembles -- Allatom folding simulations -- Understanding protein folding pathways at atomic detail.…”
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Protein degradation

Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Protein crystallography

Table of Contents: “…Contents: Protein crystallography -- Protein crystallization methods -- Crystal symmetry -- X-ray intensity data collection -- Electron density equation -- The Patterson function -- Multiple isomorphous replacement phasing -- Fitting the electron density with a model -- Refinement of the model -- Estimating quality of the model.…”
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