Search Results - "melanoma"

Disorders of pigmentation melanoma /

Table of Contents: “…Contents: Melanocyte development -- Key factors regulating lineage development -- Relationships to pigmentation diseases -- MITF -- IV-induced pigmentation -- Melanoma-genesis -- Melanoma oncogene discovery -- BRAF-targeted therapy -- Immunotherapy -- Red pigment and melanoma-genesis.…”
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RAS and RAF signaling in melanoma biology and therapies /

Table of Contents: “…Contents: Melanoma -- BRAF and RAS mutated in approximately 70% of cases -- Mouse models of melanoma -- Oncogenic BRAF can be a founder mutation in melanoma -- Mouse models replicate human disease -- BRAF inhibitors induce paradoxical activation of CRAF and drive pathway activation -- Kinase-dead BRAF mimics this and potentiates RAS ooncogenesis -- BRAF inhibitors induce excellent responses in patients, but may induce mechanism-based side effects through CRAF.…”
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Update on therapies for metastatic melanoma

Table of Contents: “…Contents: Overview of new treatments approved for advanced melanoma in the past few years -- Pegylated interferon alfa-2b -- Ipilimumab -- Mechanism of action -- Impact on progression-free and overall survival -- Overview of immune-related adverse events -- Vemurafenib -- Mechanism of action -- Impact on progression-free and overall survival -- Induction of secondary squamous cell carcinomas -- Possible role for combined RAF/MEK inhibition -- A "standard" approach to treatment of stage IV melanoma.…”
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Immune checkpoint blockade in melanoma

Table of Contents: “…Contents: Checkpoint inhibition in melanoma -- Immunotherapy in the adjuvant setting -- Biomarkers of immune response -- The future of immunotherapy in melanoma -- Targeting release of cancer antigens -- Targeting cancer antigen presentation -- Targeting priming and activation of the immune system -- Targeting trafficking and infiltration of T-cells -- Targeting recognition and killing of cancer cells.…”
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Cancer pathology

Table of Contents: “…Contents: Cancer pathology -- Histology -- Melanoma -- GI colon cancer -- Breast cancer.…”
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Cancer vaccines part 1 of 2 /

Table of Contents: “…Contents: The hallmarks of cancer -- Categories of cancer-associated antigens -- Viral & non-viral cancers: vaccine targets -- Immunotherapeutics -- Immunologic reagents approved for cancer therapy -- Clinical outcome based on immune response -- CTL-based therapy -- Virus-specific CTL adoptive transfer therapy -- Immunotherapy for Melanoma.…”
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The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /

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Talimogene laherparepvec first-in-class oncolytic immunotherapy /

Table of Contents: “…Contents: Causing tumour cell lysis -- Initiating a specific systemic immune response -- T-VEC as an oncolytic HSV-1 strain -- Assessing cancer immunotherapy through melanoma -- Applicability of oncolytic viral therapy to various cancers.…”
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Fundamental principles of positron emission tomography (PET) part 2 of 2 /

Table of Contents: “…Contents: Aspects of PET imaging -- Image reconstruction -- Filtered Back Projection -- Iterative reconstruction -- Reconstruction comparison -- Factors affecting scanner sensitivity -- 2D and 3D -- Increase in sensitivity in 3D over 2D -- Disadvantages of 3D imaging: loss of contrast & image quality -- Improved sensitivity -- Quantitative PET performance -- Phantom study -- Motion effects -- Partial volume effect -- PET data acquisition schemes -- Static & dynamic modes -- Gated PET -- Time of flight (TOF) acquisition -- Hybrid scanner: PET/CT imaging -- Rationale of PET/CT -- Types of artifacts -- Current PET/CT scanner status -- Different types of PET/CT scanners -- Radiation exposure -- Available dosimetry tools -- PET applications -- Scanning Melanoma, Lymphoma and Brain Astrocytoma -- Imaging in Neurology: Parkinson's disease -- Receptor binding -- Imaging in Cardiology.…”
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A novel cancer therapy to stimulate oncogenic ERK signalling

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Checkpoint blockade in cancer immunotherapy

Table of Contents: “…Contents: Activation of naive T-cells -- CD28 and CTLA-4 -- Differential regulation of T-cell responses -- Responding repertoire -- Biological role of CTLA-4 -- Tumor-specific immune responses -- Treg activity -- CTLA-4/GVax -- Immunotherapies -- Conventional therapies -- Ipilumumab -- Clinical studies: melanoma -- Reversible immune mediated toxicity.…”
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Understanding hormones mechanisms of androgen receptor function in reproduction and cancer /

Table of Contents: “…Contents: Mechanisms of androgen action -- Biological basis for androgen potency -- Androgen receptor FXXLF motif and N/C interaction -- Androgen receptor coactivator melanoma antigen gene protein-11 -- Androgen receptor mutations in the androgen insensitivity syndrome and prostate cancer -- Mechanisms of prostate cancer progression to castration-recurrent disease.…”
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Diagnostic immunohistopathology

Table of Contents: “…Contents: Techniques for identification and immunocytochemical study of proteins -- Leucocyte-associated molecules -- Immunhistological labeling -- Immunohistological studies of human tissue -- The first monoclonal anti-leucocyte antibodies -- Paraffin reactive monoclonal antibodies -- Protein conformation and antigenicity -- Immunohistological markers for the study of solid tumors -- Carcinoma, seminoma, mesothelioma, melanoma and carcinoid tumors -- Immunohistological markers for the diagnosis of lymphoid neoplasms -- Anaplastic large cell lymphoma -- New labeling techniques -- New antibodies and molecular targets.…”
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