Search Results - "influenza"

Influenza antivirals update /

Table of Contents: “…Contents: Antivirals for influenza-historical perspectives -- Influenza virus replication and sites of inhibition -- Principal antiviral agents for influenza -- Detecting the emergence of resistant virus -- Influenza prevention in households -- Antiviral-resistant viruses with differing circulation -- NA inhibitors for treatment -- NA inhibitors for chemoprophylaxis -- Post-exposure prophylaxis (PEP) -- NAI resistance -- Newer and investigational influenza antivirals -- Antiviral combinations.…”
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Influenza virus pandemics past and future /

Table of Contents: “…Contents: Influenza virus, the agent and the disease -- Epidemiology in humans and animals -- The 1918 pandemic & reconstruction of the virus -- Highly pathogenic avian influenza virus -- Future influenza pandemics -- Antiviral drugs against influenza -- Influenza virus vaccine formulations (types & usage frequency).…”
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Controlling pandemic flu

Table of Contents: “…Contents: The power of infection -- Three levels of protection -- The influenza virus -- The influenza vaccine -- Anti-viral drugs -- The three faces of hygiene -- 2009 swine flu outbreak -- Flu pandemics -- years of life lost -- Bird flu -- The common cold clinic -- influenza research in Retroscreen virology -- Influenza virus components -- The 1918 flu pandemic -- Researching the new virus on the front -- What's needed for an influenza virus to emerge? …”
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The making of an influenza pandemic

Table of Contents: “…Contents: Classification, structure and nomenclature -- The history of influenza -- The history of human pandemics and recent pandemic threats -- Pandemic versus seasonal influenza -- Antigen recycling -- Relation between animal and human influenza -- Antigen shift -- Modes of pandemic emergence -- Characteristics of human pandemics -- Summary -- Further reading.…”
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The future of influenza vaccines

Table of Contents: “…Contents: Influenza virion structure -- Available flu vaccines -- Problems with current inactivated vaccines -- Live attenuated vaccines -- Subunit vaccine -- New, recently licensed vaccines -- Flu vaccines in development -- Experimental vaccines -- Issues with pandemic vaccines -- Universal influenza vaccines -- The HA protein.…”
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Responding to pandemic influenza

Table of Contents: “…Contents: Healthcare and societal impacts of a pandemic -- Pandemic preparedness -- Surveillance and monitoring of a pandemic -- Public health countermeasures -- Antiviral drugs (influenza) -- Pandemic influenza vaccines -- Healthcare capacity and capability -- Pandemic communications -- Bioethical issues -- Training and exercising.…”
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Non HIV anti virals

Table of Contents: “…Contents: Pharmacokinetics and clinical application of antiviral agents excluding antiretrovirals for HIV -- The therapeutic and prophylactic options for herpes infections including herpes simplex 1 and 2, varicella zoster and cytomegalovirus -- Therapeutic and prophylactic agents for influenza -- Approved agents for the treatment of hepatitis B and C.…”
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Vaccines and the fight against antimicrobial resistance 1

Table of Contents: “…Typhi polysaccharide conjugate vaccines -- Seasonal influenza vaccines -- Rotavirus vaccines.…”
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Antiviral drugs (non-HIV)

Table of Contents: “…-- Overview of approved antiviral drugs -- Antiviral targets mechanisms and resistance -- Hepatitis C virus: biology and current drugs -- Hepatitis B virus: biology and treatments -- Herpesvirus drugs -- Influenza virus: approved drugs -- Broad-spectrum antivirals -- Diseases for which we need antivirals.…”
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Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide

Table of Contents: “…Contents: Lower respiratory infections -- Global distribution of mortality among children -- Community-acquired pneumonia in children -- Causes of severe acute respiratory infections -- The three classifications of viruses -- Zoonosis: new viruses -- Coronaviruses and SARS -- Avian influenza -- Hendra virus -- Nipah virus -- Emergence of new zoonotic viruses -- Newly recognized causes of ALRI -- Rhinovirus -- Para-influenza 4 -- Coronaviruses NL63 & HKU1 -- Newly discovered viruses -- Human metapneumovirus -- Human bocavirus -- Polyomaviruses, WU and KI -- Mimivirus -- Importance of newly discovered ALRTI causes -- Requirements for further research.…”
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Understanding statistics in epidemics and pandemics lessons learned from COVID-19 /

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Successes and failures with vaccines

Table of Contents: “…Contents: New strategies for vaccine development -- Influenza vaccines need improvement -- The microbiome influences rotavirus vaccine efficacy -- Vaccines against cytomegalovirus -- Vaccines against human papillomavirus and cervical cancer -- Insights from structural biology and the development of vaccines against respiratory syncytial virus -- Vaccines based on DNA and RNA.…”
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Innate recognition of viruses

Table of Contents: “…Contents: Induction of the adaptive Immunity -- Pattern recognition receptors: coupling innate to adaptive immunity -- Induction of type I IFNs: an example of recognition of viral patterns -- Cytosolic pathway for influenza virus recognition and inhibition by the viral -- NSI protein -- RIG-I-mediated recognition of influenza virus genomes and 5'-PPP-RNA -- Cytosolic 5'-PPP-RNA as a PAMP -- Plasmacytoid DC and the discovery of a second pathway for innate recognition of influenza virus -- Endosomal pathways for virus recognition: TLR7, TLR9 -- TLR3 as a sensor of virally-infected cells.…”
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Haemophilus

Table of Contents: “…Contents: Hemophilus influenzae -- Virulence determinants -- Immunization strategies -- Hib -- Other serotypes -- Basic structure of the H. influenzae LOS -- Sialic acids and virulence -- Phosphorylcholine (PCho) and virulence -- Phase variable genes -- Iron utilization systems -- Resistance to effectors of innate immunity -- Adhesins -- Other Haemophilus species associated with human health and disease -- Haemophilus ducreyi…”
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Antivirals versus vaccines

Table of Contents: “…Contents: Emerging infections in the past decades -- Human respiratory viruses -- The AIDS pandemic -- HIV vaccine approaches -- Antivirals use against HIV -- Morbilliviruses -- Metapneumovirus -- hMPV -- SARS-CoV -- Candidate SARS vaccines -- Vaccination of macaques against SARS -- Henipahvirus -- Smallpox -- History of smallpox vaccination -- Antiviral drugs against smallpox -- Cidofovir -- Human influenza: three appearances -- Avian influenza A virus: adaptation -- H1N1 virus: relevant mutations -- The Mexican flu virus -- Pre-pandemic H5N1 clinical trials -- The importance of an adjuvant -- Seasonal vaccine and pandemic A/H1N1 -- Flu drugs targets.…”
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The past, present and future of vaccination

Table of Contents: “…Contents: History of vaccines, with four lessons of vaccinology -- New vaccines, including those against rotavirus, influenza, zoster and human papillomaviruses -- New strategies of vaccine development, including recombinants, vectors, plasmid DNA and non-parenteral routes of administration.…”
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Glycoprotein maturation and quality control in the endoplasmic reticulum

Table of Contents: “…Contents: Protein maturation in the secretory pathway -- ER glycoforms -- The glyco-code of the ER -- Calnexin and calreticulin -- Cotranslational folding -- Influenza hemagglutinin -- Oxidation of HA -- HA truncations -- Type I membrane proteins -- Disease states involving ER folding and quality control -- Structural determinants that cause retention -- ER retention signals -- Calnexin binding cycle -- GT or UDP glucose glycoprotein: glycosyltransferase -- Degradation of misfolded proteins -- Carbohydrate trimming -- EDEM1 functions.…”
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Structure-based drug design targeting infectious disease

Table of Contents: “…Contents: Many antibiotics inhibit the ribosome -- Intelligent engine builds perpetual pipeline -- Crystallography shows 50S is a target-of-targets -- From new X-ray crystals to new leads -- Analog(Trade Mark) -- LINKER essentials: tethering two binding features -- BOMB essentials -- MUSIC essentials: core-swapping -- QikProp: calculating drug-like properties -- Structures + Analog(Trade Mark): balanced compounds -- Case study: enhanced oxazolidinones -- Structural foundations -- Path to enhanced oxazolidinones -- Pi contributions represent key interactions -- Probing selectivity of sparsomycin -- Seeking a new lead -- Difference density map showing rib-X prototype -- Perfect match -- A minimal scaffold for lead optimization -- Minimal scaffold binds effectively in A-site -- Activity against H. influenzae -- H. influenzae activity with time evolution -- H. flu model delivers differentiable oxazolidinones -- Moderate in vivo activity measured -- Predictive model for rat oral bioavailability -- First pool of drug candidates -- Structures + predictive models = time-saving filters.…”
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Adipose-immune interactions in obesity

Table of Contents: “…Contents: Adipoimmunology -- The adipose organ in obesity -- The immune system -- Adipose tissue macrophages and inflammation -- Differentiation of macrophages -- Effect of obesity on adipose tissue macrophages -- Macrophages cause insulin resistance in obesity -- ATM polarization model -- Future directions: ATM and adipose tissue -- Adipose tissue lymphocytes and inflammation -- T-lymphocytes subsets -- CD3+ T cells are present in the adipose tissue -- Age related increased bone-marrow adipocity -- Age related thymic adipocity -- T cells develop in the thymus -- The effect of thymic involution -- Lineage of thymic adipocytes -- Loss of ghrelin signaling and thymic adiposity -- reduction in naive T cells -- Adipose secretory products and immune cells -- Effect of obesity on immune function -- Obesity induced by monogenic leptin deficiency -- Dietary obesity reduces lymphoid cellularity -- Dietary obesity induces apoptosis of T cells -- Influenza infection.…”
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