Search Results - "essentialism"

Creating customer value : the essentials of marketing / by Wharton

Creating customer value : the essentials of marketing by Learning Resources

O-GlcNAc, an essential regulator of numerous cellular pathways

“…O-linked beta-N-acetylglucosamine, an essential regulator of numerous cellular pathways…”
Get full text
Series

Biogenesis of cellular iron-sulfur proteins part II, the essential role of mitochondria and the CIA machinery /

“…Biogenesis of cellular iron-sulfur proteins. Part 2, The essential role of mitochondria and the CIA machinery…”
Get full text
Series

Photoreceptor protection significance of docosanoids and elovanoids. Part 1 of 2, docosahexaenoic acid (DHA) /

Table of Contents: “…Contents: Biosynthesis of docosanoids -- Essential fatty acids -- Neuroprotective bioactivity during oxidative stress -- AdipoR1 as a regulatory switch of the DHA.…”
Get full text
Series

Guinea worm a case study of an eradication programme /

Table of Contents: “…Contents: Guinea worm essentials -- The certification process -- Guinea worm eradication essential interventions and components -- Unsafe water source -- Innovative approaches including reward -- Animal infection -- Epidemiology in Chad -- Mali -- Measuring and documenting surveillance and response.…”
Get full text
Series

Gastric cancer, gastritis and the role of H. pylori

Table of Contents: “…Contents: Helicobacter pylori (Hp) and gastric cancer -- Natural history of Hp gastritis -- Hp an essential risk factor -- Mechanisms of carcinogenesis -- Why the variation in cancer incidence?…”
Get full text
Series

The genetic structure of Mycobacterium tuberculosis insights into genome organisation and evolution of the causative agent of tuberculosis /

Table of Contents: “…Contents: Mycobacterium tuberculosis -- genome information -- essential genes- virulence genes -- type VII secretion system involved in virulence and host pathogen interaction- genomics and evolution of tuberculosis-causing mycobacteria.…”
Get full text
Series

Structure-based drug design targeting infectious disease

Table of Contents: “…Contents: Many antibiotics inhibit the ribosome -- Intelligent engine builds perpetual pipeline -- Crystallography shows 50S is a target-of-targets -- From new X-ray crystals to new leads -- Analog(Trade Mark) -- LINKER essentials: tethering two binding features -- BOMB essentials -- MUSIC essentials: core-swapping -- QikProp: calculating drug-like properties -- Structures + Analog(Trade Mark): balanced compounds -- Case study: enhanced oxazolidinones -- Structural foundations -- Path to enhanced oxazolidinones -- Pi contributions represent key interactions -- Probing selectivity of sparsomycin -- Seeking a new lead -- Difference density map showing rib-X prototype -- Perfect match -- A minimal scaffold for lead optimization -- Minimal scaffold binds effectively in A-site -- Activity against H. influenzae -- H. influenzae activity with time evolution -- H. flu model delivers differentiable oxazolidinones -- Moderate in vivo activity measured -- Predictive model for rat oral bioavailability -- First pool of drug candidates -- Structures + predictive models = time-saving filters.…”
Get full text
Series

Deep Brain Stimulation (DBS) neuromodulation for Schizophrenia

Table of Contents: “…Contents: General characteristics of schizophrenia -- Unmet needs in patients -- Amenability of the patient population to DBS -- Comparing schizophrenia to Parkinson's disease, essential tremor & dystonia -- Targets and risks of DBS -- When risks outweigh benefits of DBS.…”
Get full text
Series

Genomic Imprinting

Table of Contents: “…Contents: Genomic Imprinting: Definition of genomic imprinting -- Why genomic imprinting is essential for development -- Imprinted genes -- Mechanism of genomic imprinting -- H19/Igf2 imprinted locus -- Marking of imprinted genes in the germline -- Maintenance of genomic imprints.…”
Get full text
Series

Designing proteins with life sustaining activities part 1 of 2 /

Table of Contents: “…Contents: Protein design & synthetic biology -- Designing novel proteins using a hybrid approach -- Combinatorial libraries of novel proteins -- Folding of novel proteins into stable structures -- Biochemical activity of novel proteins in vitro (binding & catalysis) -- Essential biological functions provided by novel proteins in vivo.…”
Get full text
Series

Multiple myeloma an overview /

Table of Contents: “…Contents: Introduction to the diagnosis of multiple myeloma -- Related plasma cell disorders such as MGUS/Smouldering Myeloma -- Diagnostic criteria -- Staging and prognosis including revised international staging (RIS) -- Essential laboratory tests -- Cytogenetics and chromosomal changes in myeloma -- Overview of myeloma treatment -- New and emerging drugs in myeloma.…”
Get full text

Implementation of adaptive methods in early phase clinical trials

Table of Contents: “…Contents: Practical guidance on implementing adaptive designs in early-phase clinical trials -- Essential protocol information that leads to acceptance of the design and directs implementation -- Issues that need to be considered and addressed prior to starting an adaptive design -- Examples & general check list on designing and implementing early-phase adaptive designs.…”
Get full text
Series

The kinetochore as a target for the development of mitosis specific anti-cancer drugs

Table of Contents: “…Contents: Mitosis is critical for cells to proliferate and is a major target of current anti-cancer drugs such as paclitaxel and vinca alkaloids -- Characterization of proteins essential for mitosis has made available the opportunity to develop new anti-mitotic agents -- Expanding the number of anti-cancer drug targets should significantly improve the response of tumors to chemotherapies.…”
Get full text
Series

Control of growth the Drosophila Myc homolog /

Table of Contents: “…Contents: The Myc oncogene in vertebrates -- Molecular function of Myc -- Normal function of Myc -- Myc in other taxa -- Myc in Drosophila melanogaster -- Myc controls animal size, endoreplication, apoptosis, cell competition and asymmetric division -- Molecular function of Myc in Drosophila melanogaster -- Ribosome synthesis -- Max-independent activities -- Genetic screening can reveal essential partners.…”
Get full text

Identification of host defenses in the Drosophila gut using genome-scale RNAi

Table of Contents: “…-- Drosophila digestive tract -- Intestinal barriers against pathogens -- The imd pathway in preventing infection -- Serratia marcescens, an opportunistic pathogen -- Genome wide RNA-I screening to identify essential genes for host defense -- Gene ontology of the hits from RNA-I screening -- The JAK/STAT pathway -- The components of host defenses to infections -- Serratia hemolysins.…”
Get full text
Series

Polycomb epigenetic mechanisms Part 2 of 2, methylation of DNA /

Table of Contents: “…Contents: PRC2 has an untargeted global function -- Chromatin immunoprecipitation (ChIP-seq) profiles -- H3K27 methylation -- The CBP/p300 acetylase complex -- The TRR complex (MLL3,4 in mammals) -- The DNA accessibility model -- How do PcG complexes repress? -- The essential role of canonical PRC1 -- Links between PRC1 and PRC2 -- The bivalent state.…”
Get full text
Series

Infectious conjunctivitis

Table of Contents: “…Contents: Bacterial conjunctivitis: less common than viral conjunctivitis in adults -- Treatment of bacterial conjunctivas: often started empirically -- Topical antibiotics should not be used to treat viral conjunctivitis -- Hyperacute gonococcal conjunctivitis can progress rapidly to involve the cornea: systemic treatment is essential -- Chlamydial conjunctivitis causes a chronic follicular conjunctivitis that is treated with systemic medication -- Blepharoconjunctivitis: a chronic conjunctivitis that requires concomitant treatment of the eyelids.…”
Get full text

Race in genetics and medicine

Table of Contents: “…Contents: Questions about race -- Fundamentals of DNA and the genome -- Human genome sequence -- DNA sequence variation -- Three essential features of human genome diversity -- Expected nucleotide diversity -- STR analysis -- Relationships among human populations -- Major long-range human migrations -- Definition of race -- Allocation of individuals to genetic clusters -- Principal pathway of ethanol metabolism -- Allele frequencies at ALDH2 locus -- European ancestry and diabetes risk.…”
Get full text
Series