Search Results - "distortion"

Human population growth and its impact on genetic variation

Table of Contents: “…Contents: Brief introduction to population genetics -- The neutral coalescent & its distortion by population growth -- The site frequency spectrum -- Growth results in excess of rare variants -- Mutation rate & its estimation from rapidly growing populations -- Growth results in allelic heterogeneity -- Different rare variants at disease-causing loci.…”
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Translocation movement of tRNA and mRNA through the ribosome /

Table of Contents: “…-- The mRNA channel in the 30S subunit -- Positions of tRNA in the A-, P- and E-sites -- Structural dynamics of the ribosome during translocation -- The hybrid states elongation cycle -- tRNA binding during its movement through the ribosome -- The 70S ribosome -- Distortion of tRNA structure by the ribosome -- The ratchet model -- Cryo-EM experiment -- Inferred relationship between ratcheting and hybrid states -- FRET changes -- Intersubunit movement -- Testing the ratchet model for translocation -- Translocation assay -- What defines the mechanism of translocation -- Sparsomycin -- The energetics of translocation -- E-site tRNA -- The ribosome is a molecular machine.…”
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