Search Results - "creationism"

Creation of tools for the investigation of oxidative damage to nucleic acids

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Novel immunotherapeutic proteins immunoligand /

Table of Contents: “…Contents: Potential advantages of mAB -- Challenges for mAB -- Antibody based therapeutic proteins -- Attributes of immunoligands -- Creation of Ig-based fusion proteins -- Non-cytolytic IL-2/Fc fusion protein -- Vaccine trial design -- Creation of cytolytic IL-15R antagonist fusion protein -- Application of immunoligand: immunogen for mAB production, to stain the cognate ligand, to identify cell surface cognate ligands via immunoprecipitation, to create long lived proteins to test the function of the targeting ligand in vivo and to modulate immune responses -- Challenges for immunoligands.…”
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Drooling and sialorrhoea

Table of Contents: “…Contents: Defining sialorrhoea & drooling -- Causes for drooling in children and adults -- Drooling & neurological disorders -- Effects of drooling -- Tools for drooling assessment -- Pharmacological approaches vs. surgical procedures -- The creation of a "drooling team" -- Individualised therapeutic strategy.…”
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Use of technology and document management systems for SOPs

Table of Contents: “…Contents: Using technology or EDMS for SOPs -- The place of paper and of technology -- A basic EDMS -- What to expect from your EDMS -- Meta data -- Document versioning, publishing & security -- Collaborative creation -- Work flow -- Electronic signatures -- Linking documents -- Guidance for associated documents -- Forms & templates -- Using a bridging document -- Thoughts for the future.…”
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Storing, searching and dissemination of chemical information

Table of Contents: “…Optimum structure -- Problems of hash methods -- Matching of data -- Index creation -- Chemical exact structure and substructure search -- Brute-force explanation -- ABAS in practice -- Heuristic backtracking in molecular tree -- The concept of screening -- Tanimoto coefficient -- Chemical reaction retrieval -- Atom-to-atom mapping -- Breaking/Formation of bonds -- Super atoms, generic groups, R groups -- Generation of synthesis trees for synthesis -- Document and fact retrieval -- Exact & Partial match searches -- Similarity & Associative searches.…”
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Structure, evolution and dynamics of transcriptional regulatory networks

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Transcriptional networks -- Network motifs -- Scale-free networks -- How transcriptional networks evolve -- Mechanisms for the creation of new genes -- Gene duplication and network growth -- Evolution of local network structure -- Gene regulatory network and expression data -- Back-tracking method to find active sub-networks -Temporal dynamics of local & global structure -- Topological properties -- Dynamic properties -- Hierarchical organisation in networks & of regulatory proteins -- Noise in protein levels -- Non-genetic variation -- Phenotypic variability in fluctuating environments -- Differential cell-fate outcome -- Node dynamics.…”
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Safety pharmacology in human pharmaceutical development

Table of Contents: “…Contents: Adverse functional effects of drugs on vital organ systems have resulted in patient deaths and several product withdrawals over the past two decades -- The potential for these effects was not detected in the traditional toxicology studies that were conducted at the time -- These unfortunate events have led to the introduction of new international regulatory guidelines and the creation of a new discipline, known as safety pharmacology, which is distinct from toxicology -- Safety pharmacology involves experts in pharmacology who specialize in acute adverse effects of potential human drugs, primarily on the cardiovascular, respiratory and central nervous system -- These three organ systems have been deemed to be the ones that are acutely critical for life -- If safety pharmacology studies had been conducted in the past, according to today's standards, the vast majority of the drugs that resulted in human deaths would never have made it.…”
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A paradigm shift in the brain-immune relationships infiltrating macrophages in central nervous system repair /

Table of Contents: “…Contents: The CNS immune enigma -- CNS response to injury -- Recruitment of macrophages is insufficient -- Site, dose, timing for macrophage implantation -- Local and systemic immune response -- Circulating T cells are needed for recovery -- Protective autoimmunity vs. autoimmune disease -- Two faces of macrophages -- Creation of chimeric mice with head protection -- Macrophages play anti-inflammatory role -- Transferred monocytes promote repair -- T-cells boost monocyte recruitment -- Macrophages resolve microglia response -- The glial scar regulates microglia / macrophages -- CSPG production and degradation -- CSPG and the IL-10 expressing monocytes -- Co-localization of macrophages with the glial scar -- Location determines macrophage phenotype -- Macrophages and neuroprotection in the retina -- Macrophages support progenitor cell renewal -- Monocyte recruitment is limited -- Type, phenotype, location, timing -- Neurogenesis: highest manifestation of plasticity -- CNS specific autoreactive T cells -- Spatial memory -- The immunological malfunction -- Immunity to self and self-maintenance -- Local and systemic inflammation -- Circulating cells fight local inflammation -- Recruitment of monocytes in Alzheimer -- From immune deficiency to brain malfunction.…”
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