Search Results - "conducting"

Design and conduct of equivalence trials

Table of Contents: “…Contents: Equivalence trial study design -- Selection of an acceptable margin of equivalence/non-inferiority -- Selection of the control (placebo/active/both) -- Confidence interval or hypothesis testing -- Approach -- Analysis population -- Trial conduct.…”
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Design and conduct of non-inferiority trials

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Series (Risk of bias in randomized clinical trials)
Series (Design and analysis of randomized clinical trials)

Voices of young mothers / by TVE International

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Vixens and virgins and other mythological creatures how teenage girls see themselves /

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The heart and pericardium

Table of Contents: “…Contents: Anatomy of the heart -- Anatomy of the thorax -- The mediastinum -- Vascular supply of the heart -- Conduction system of the heart -- Features of the heart.…”
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Action potentials

Table of Contents: “…Contents: Membrane potential -- Voltage-gated sodium channels -- Voltage-gated potassium channels -- Movement of ions during an action potential -- Refractory periods -- Conduction velocity -- Myelination -- Saltatory conduction.…”
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M-current and its role in neuronal physiology

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Membrane potential

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Regulation of neuron accuracy by modulation of potassium channels

Subjects: “…Neural conduction. 86561…”
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Bacterial activation of epithelial signaling

Subjects: “…Cystic Fibrosis Transmembrane Conductance Regulator. 85124…”
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Laboratory methods for the in vitro study of drug metabolism

Table of Contents: “…Contents: Major classes of drug-metabolizing enzymes -- Co-factor requirement for in vitro incubations -- Practical aspects of conducting in vitro assays -- In vitro assays conducted during drug discovery and development -- Clearance estimation -- Kinetic parameter determination -- Enzyme inhibition -- Enzyme induction -- Enzyme reaction phenotyping.…”
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The role of chaperones and Sec machinery in protein secretion

Table of Contents: “…Contents: Importance of protein translocation -- Identification of Sec factors -- Structure and function of translocon, an evolutionarily conserved membrane protein complex that serves as a polypeptide-conducting channel -- Structure and function of SecA, a translocation-driving ATPase -- Unique regulation of SecA by SecM, a protein that interacts with the ribosomal exit tunnel.…”
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Acute, subchronic, and chronic toxicity testing

Table of Contents: “…Contents: Purpose of acute, subchronic, and chronic general toxicology testing -- Regulations and guidelines on conduct -- Considerations and components to consider during study design -- Differences between small and large molecule toxicology study designs.…”
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Elimination of lymphatic filariasis adapting to reach the end game /

Table of Contents: “…Contents: Lymphatic filariasis -- Wuchereria bancrofti -- Transmission of LF -- Diagnostic tools for LF -- Drugs to treat LF -- LF elimination strategy -- Conducting mass drug administration -- How do we measure progress and success? …”
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Safety pharmacology in human pharmaceutical development

Table of Contents: “…Contents: Adverse functional effects of drugs on vital organ systems have resulted in patient deaths and several product withdrawals over the past two decades -- The potential for these effects was not detected in the traditional toxicology studies that were conducted at the time -- These unfortunate events have led to the introduction of new international regulatory guidelines and the creation of a new discipline, known as safety pharmacology, which is distinct from toxicology -- Safety pharmacology involves experts in pharmacology who specialize in acute adverse effects of potential human drugs, primarily on the cardiovascular, respiratory and central nervous system -- These three organ systems have been deemed to be the ones that are acutely critical for life -- If safety pharmacology studies had been conducted in the past, according to today's standards, the vast majority of the drugs that resulted in human deaths would never have made it.…”
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Population genetic studies in Africa curiosity and challenges /

Table of Contents: “…Contents: Use of genomic DNA to advance our knowledge and understanding of human evolution, biomedical research and mechanisms of disease -- Acquiring specimens for research -- Strict policies and recommendations guiding specimen acquirement -- Social, ethical and legal issues when conducting research on human subjects -- Factors to be considered when setting up qualitative and quantitative research -- Case study: sub-Saharan Africa, in particular population genetics studies.…”
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Behavior intervention and autism

Table of Contents: “…-- Positive behavior support -- Communication and behavior -- General issues regarding problem behaviors -- Why conduct a functional analysis? -- Identifying replacement behaviors -- Teaching new behaviors.…”
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The impact of DNA sequencing technology on agriculture

Table of Contents: “…Contents: Genomics and the world's most important crops -- Traditional breeding and limitations -- Domestication bottleneck -- Genomics-assisted breeding -- Conducting a sequencing project -- Sample preparation -- Library preparation -- Reduced representation sequencing -- Multiple sequencing technology options -- Data processing -- Post-processing -- Genotyping platforms -- Applications of the data -- Understanding genetic architecture -- Mapping the genome -- QTL mapping -- Genome-wide association mapping -- From QTL to candidate gene -- Alternative to MAS -- Keys to success for accelerated crop breeding -- Hot areas for the future of breeding -- Advancement of underutilized crops -- Improving global food security.…”
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Roles for molecular chaperones in cystic fibrosis

Table of Contents: “…Contents: Cystic fibrosis is a fatal homozygous recessive disorder -- Caused primarily by misfolding of mutant forms of cystic fibrosis transmembrane conductance regulator (CFTR) -- The folding defects in mutant CFTR are detected by protein quality control machines in the endoplasmic reticulum that target mutant CFTR for premature degradation -- Small molecules that are being developed as drugs to treat cystic fibrosis enable mutant CFTR to avoid recognition by the endoplasmic reticulum quality control system and function at the cell surface.…”
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Toxicology testing standards good laboratory practices and the institutional animal care committee /

Table of Contents: “…Harvey Wiley, his "Poison Squad" and the Pure Food and Drugs Act that lead to the founding of the FDA in the 20th century -- Thalidomide, scientific fraud and the promulgation of the Good Laboratory Practices regulations -- Outrage over Upton Sinclair's book "The Jungle", the Animal Welfare Act and how this lead to the formation of Institutional Animal Care and Use Committees (IACUC) -- How study protocols are developed and GLP studies conducted with IACUC input and oversight.…”
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