Search Results - "argumentation"

Ethical considerations in dealing with CNV information

Table of Contents: “…-- Existing guidelines on returning results -- National Bioethics Advisory Commission -- UK Biobank -- NIH guidelines -- Arguments FOR returning CNV results -- Arguments AGAINST returning CNV results -- Avoiding CNV exceptionalism -- What results mean to families -- What we still need to know.…”
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Ethical considerations in dealing with CNV information

Table of Contents: “…-- Existing guidelines on returning results -- National Bioethics Advisory Commission -- UK Biobank -- NIH guidelines -- Arguments FOR returning CNV results -- Arguments AGAINST returning CNV results -- Avoiding CNV exceptionalism -- What results mean to families -- What we still need to know.…”
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Ethical considerations in dealing with CNV information

Table of Contents: “…-- Existing guidelines on returning results -- National Bioethics Advisory Commission -- UK Biobank -- NIH guidelines -- Arguments FOR returning CNV results -- Arguments AGAINST returning CNV results -- Avoiding CNV exceptionalism -- What results mean to families -- What we still need to know.…”
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Nuclear cloning, stem cells and epigenetic reprogramming the promise for "customized" tissue repair /

Table of Contents: “…Contents: Transfer of somatic cell nuclei into enucleated oocytes for full term development of mammals -- genomic reprogramming -- the use of ES cells, terminally differentiated lymphoid cells, neurons and cancer cells as donors for nuclear transplantation -- use of Somatic Cell Nuclear Transfer (SCNT) for "therapeutic cloning" -- scientific evidence vs. moral arguments.…”
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Nuclear cloning, stem cells and epigenetic reprogramming

Table of Contents: “…Contents: Transfer of somatic cell nuclei into enucleated oocytes for full term development of mammals -- genomic reprogramming -- the use of ES cells, terminally differentiated lymphoid cells, neurons and cancer cells as donors for nuclear transplantation -- use of Somatic Cell Nuclear Transfer (SCNT) for "therapeutic cloning" -- scientific evidence vs. moral arguments.…”
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Nuclear cloning, stem cells and epigenetic reprogramming

Table of Contents: “…Contents: Transfer of somatic cell nuclei into enucleated oocytes for full term development of mammals -- genomic reprogramming -- the use of ES cells, terminally differentiated lymphoid cells, neurons and cancer cells as donors for nuclear transplantation -- use of Somatic Cell Nuclear Transfer (SCNT) for "therapeutic cloning" -- scientific evidence vs. moral arguments.…”
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Understanding obesity genes and environment in the determination of body weight /

Table of Contents: “…Contents: Evolutionary arguments for regulation of body fat -- Gene x gene x environment interactions -- Molecular physiology of control of body weight -- Human monogenic obesities -- Complex genetics of human obesity -- Threshold model for control of body weight -- Bioenergetics of reduced body weight -- Structural plasticity in the CNS systems regulating body fat.…”
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Understanding obesity genes and environment in the determination of body weight /

Table of Contents: “…Contents: Evolutionary arguments for regulation of body fat -- Gene x gene x environment interactions -- Molecular physiology of control of body weight -- Human monogenic obesities -- Complex genetics of human obesity -- Threshold model for control of body weight -- Bioenergetics of reduced body weight -- Structural plasticity in the CNS systems regulating body fat.…”
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Understanding obesity genes and environment in the determination of body weight /

Table of Contents: “…Contents: Evolutionary arguments for regulation of body fat -- Gene x gene x environment interactions -- Molecular physiology of control of body weight -- Human monogenic obesities -- Complex genetics of human obesity -- Threshold model for control of body weight -- Bioenergetics of reduced body weight -- Structural plasticity in the CNS systems regulating body fat.…”
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Multiple analyses in clinical trials

Table of Contents: “…Contents: Definition of a clinical trial -- The great compromise of medical research -- The populations can fool us -- Extending to the population -- Appropriate sampling -- Trustworthy estimates -- Random research -- Experimental corruption -- Prospectively designed research -- Patience and tight protocols -- Endpoints -- Community responsibility -- Investigator mandate -- P-values: pros and cons -- Evolution in trial methodology -- Argument for multiple endpoints -- Conflict within trial interpretation -- Type I error inflation -- Bonferroni correction -- Negative primary endpoints.…”
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Multiple analyses in clinical trials

Table of Contents: “…Contents: Definition of a clinical trial -- The great compromise of medical research -- The populations can fool us -- Extending to the population -- Appropriate sampling -- Trustworthy estimates -- Random research -- Experimental corruption -- Prospectively designed research -- Patience and tight protocols -- Endpoints -- Community responsibility -- Investigator mandate -- P-values: pros and cons -- Evolution in trial methodology -- Argument for multiple endpoints -- Conflict within trial interpretation -- Type I error inflation -- Bonferroni correction -- Negative primary endpoints.…”
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Multiple analyses in clinical trials

Table of Contents: “…Contents: Definition of a clinical trial -- The great compromise of medical research -- The populations can fool us -- Extending to the population -- Appropriate sampling -- Trustworthy estimates -- Random research -- Experimental corruption -- Prospectively designed research -- Patience and tight protocols -- Endpoints -- Community responsibility -- Investigator mandate -- P-values: pros and cons -- Evolution in trial methodology -- Argument for multiple endpoints -- Conflict within trial interpretation -- Type I error inflation -- Bonferroni correction -- Negative primary endpoints.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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