Search Results - "They Remain"

Transgenic mouse models of prion diseases

Table of Contents: “…Contents: Prions represent a new biological paradigm of protein-mediated information transfer -- Prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies (TSEs) -- Many unresolved issues remain including the exact molecular nature of the prion, the detailed mechanism of prion propagation, and the mechanism by which prion diseases can be both genetic and infectious -- The factors governing the transmission of prions between species remain unclear, in particular the means by which prion strains and PrP primary structure interact to affect inter-species prion transmission -- Dramatic advances in our understanding of prions have occurred because of their transmissibility to experimental animals and the development of transgenic (Tg) mouse models has done much to further our understanding about various aspects of prion biology.…”
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Transgenic mouse models of prion diseases

Table of Contents: “…Contents: Prions represent a new biological paradigm of protein-mediated information transfer -- Prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies (TSEs) -- Many unresolved issues remain including the exact molecular nature of the prion, the detailed mechanism of prion propagation, and the mechanism by which prion diseases can be both genetic and infectious -- The factors governing the transmission of prions between species remain unclear, in particular the means by which prion strains and PrP primary structure interact to affect inter-species prion transmission -- Dramatic advances in our understanding of prions have occurred because of their transmissibility to experimental animals and the development of transgenic (Tg) mouse models has done much to further our understanding about various aspects of prion biology.…”
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Transgenic mouse models of prion diseases

Table of Contents: “…Contents: Prions represent a new biological paradigm of protein-mediated information transfer -- Prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies (TSEs) -- Many unresolved issues remain including the exact molecular nature of the prion, the detailed mechanism of prion propagation, and the mechanism by which prion diseases can be both genetic and infectious -- The factors governing the transmission of prions between species remain unclear, in particular the means by which prion strains and PrP primary structure interact to affect inter-species prion transmission -- Dramatic advances in our understanding of prions have occurred because of their transmissibility to experimental animals and the development of transgenic (Tg) mouse models has done much to further our understanding about various aspects of prion biology.…”
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CML genetic paradigm of targeted therapy, part 2 of 2 /

Table of Contents: “…Contents: Mechanisms of resistance to tyrosine kinase inhibitors (TKIs) -- Overcoming resistance with second and third generation TKIs -- Remaining difficulties in eradicating CML.…”
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CML genetic paradigm of targeted therapy, part 2 of 2 /

Table of Contents: “…Contents: Mechanisms of resistance to tyrosine kinase inhibitors (TKIs) -- Overcoming resistance with second and third generation TKIs -- Remaining difficulties in eradicating CML.…”
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CML genetic paradigm of targeted therapy, part 2 of 2 /

Table of Contents: “…Contents: Mechanisms of resistance to tyrosine kinase inhibitors (TKIs) -- Overcoming resistance with second and third generation TKIs -- Remaining difficulties in eradicating CML.…”
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Initiation and elongation of mammalian mitochondrial protein synthesis

Table of Contents: “…Contents: General features of mammalian mitochondrial translation: the genetic code, tRNAs, mRNAs and ribosomes -- Initiation of translation: current working model, properties of the initiation factors -- Elongation of translation: current working model, properties of the elongation factors -- Role of the membrane and possible translational activators -- Major remaining questions.…”
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Initiation and elongation of mammalian mitochondrial protein synthesis

Table of Contents: “…Contents: General features of mammalian mitochondrial translation: the genetic code, tRNAs, mRNAs and ribosomes -- Initiation of translation: current working model, properties of the initiation factors -- Elongation of translation: current working model, properties of the elongation factors -- Role of the membrane and possible translational activators -- Major remaining questions.…”
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Initiation and elongation of mammalian mitochondrial protein synthesis

Table of Contents: “…Contents: General features of mammalian mitochondrial translation: the genetic code, tRNAs, mRNAs and ribosomes -- Initiation of translation: current working model, properties of the initiation factors -- Elongation of translation: current working model, properties of the elongation factors -- Role of the membrane and possible translational activators -- Major remaining questions.…”
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Regulation of synaptic plasticity by astroglia

Table of Contents: “…Contents: Astroglia are the most abundant type of glial cells -- Their role has recently emerged as an active contributor to neural function -- The underlying mechanisms remain poorly understood -- Astrocytes release D-serine in a Ca2+ dependent manner -- Interference with this release reduces activation of synaptic NMDA receptors -- This in turn could severely impair induction of long-term synaptic potentiation -- Astroglia thus may play a fundamental role in mechanisms of memory formation in the brain.…”
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Phagocytosis in the fruit fly, Drosophila melanogaster

Table of Contents: “…Contents: Infectious diseases remain the commonest cause of premature mortality worldwide -- The emergence of antibiotic resistant strains and the risks of bioterrorism have reinforced the importance of understanding the host-pathogen dynamic - It is hopeful that identifying the natural mechanisms used by the host to control infection will provide new avenues for therapeutic intervention -- Model organisms such as Drosophila provide well-characterized, conserved and genetically tractable systems for exploring this dynamic -- Drosophila are amenable to not only forward and reverse genetics but also hold great promise for small molecule screening and other unbiased approaches that will uncover evolutionarily conserved components of the innate immune system.…”
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Regulation of synaptic plasticity by astroglia

Table of Contents: “…Contents: Astroglia are the most abundant type of glial cells -- Their role has recently emerged as an active contributor to neural function -- The underlying mechanisms remain poorly understood -- Astrocytes release D-serine in a Ca2+ dependent manner -- Interference with this release reduces activation of synaptic NMDA receptors -- This in turn could severely impair induction of long-term synaptic potentiation -- Astroglia thus may play a fundamental role in mechanisms of memory formation in the brain.…”
Get full text
Series

Phagocytosis in the fruit fly, Drosophila melanogaster

Table of Contents: “…Contents: Infectious diseases remain the commonest cause of premature mortality worldwide -- The emergence of antibiotic resistant strains and the risks of bioterrorism have reinforced the importance of understanding the host-pathogen dynamic - It is hopeful that identifying the natural mechanisms used by the host to control infection will provide new avenues for therapeutic intervention -- Model organisms such as Drosophila provide well-characterized, conserved and genetically tractable systems for exploring this dynamic -- Drosophila are amenable to not only forward and reverse genetics but also hold great promise for small molecule screening and other unbiased approaches that will uncover evolutionarily conserved components of the innate immune system.…”
Get full text
Series

Phagocytosis in the fruit fly, Drosophila melanogaster

Table of Contents: “…Contents: Infectious diseases remain the commonest cause of premature mortality worldwide -- The emergence of antibiotic resistant strains and the risks of bioterrorism have reinforced the importance of understanding the host-pathogen dynamic - It is hopeful that identifying the natural mechanisms used by the host to control infection will provide new avenues for therapeutic intervention -- Model organisms such as Drosophila provide well-characterized, conserved and genetically tractable systems for exploring this dynamic -- Drosophila are amenable to not only forward and reverse genetics but also hold great promise for small molecule screening and other unbiased approaches that will uncover evolutionarily conserved components of the innate immune system.…”
Get full text
Series

Regulation of synaptic plasticity by astroglia

Table of Contents: “…Contents: Astroglia are the most abundant type of glial cells -- Their role has recently emerged as an active contributor to neural function -- The underlying mechanisms remain poorly understood -- Astrocytes release D-serine in a Ca2+ dependent manner -- Interference with this release reduces activation of synaptic NMDA receptors -- This in turn could severely impair induction of long-term synaptic potentiation -- Astroglia thus may play a fundamental role in mechanisms of memory formation in the brain.…”
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Herpes simplex virus antiviral chemotherapy

Table of Contents: “…Contents: Herpes simplex virus type-1 & type-2 -- Common diseases caused by HSV -- HSV infections are life-long -- All viruses are obligate intracellular parasites -- HSV-the first virus treated effectively with antivirals -- Findings for antiviral compounds -- Nucleoside analogues: successful HSV inhibitors -- Acyclovir & penciclovir have similar activity, low aqueous solubility -- Prudrugs conversion yields active compounds -- Remaining problems in HSV disease management.…”
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Herpes simplex virus antiviral chemotherapy

Table of Contents: “…Contents: Herpes simplex virus type-1 & type-2 -- Common diseases caused by HSV -- HSV infections are life-long -- All viruses are obligate intracellular parasites -- HSV-the first virus treated effectively with antivirals -- Findings for antiviral compounds -- Nucleoside analogues: successful HSV inhibitors -- Acyclovir & penciclovir have similar activity, low aqueous solubility -- Prudrugs conversion yields active compounds -- Remaining problems in HSV disease management.…”
Get full text
Series

Herpes simplex virus antiviral chemotherapy

Table of Contents: “…Contents: Herpes simplex virus type-1 & type-2 -- Common diseases caused by HSV -- HSV infections are life-long -- All viruses are obligate intracellular parasites -- HSV-the first virus treated effectively with antivirals -- Findings for antiviral compounds -- Nucleoside analogues: successful HSV inhibitors -- Acyclovir & penciclovir have similar activity, low aqueous solubility -- Prudrugs conversion yields active compounds -- Remaining problems in HSV disease management.…”
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The eye and diabetes

Table of Contents: “…Contents: Complications from diabetes -- Diabetic retinopathy -- Classification of diabetic retinopathy -- Classification of diabetic macular edema -- Clinical assessment of diabetic retinopathy -- Optical coherence tomography -- Epidemiology of diabetic retinopathy -- Strategies of diabetic retinopathy management -- Glucose control remains critical -- Blood pressure just as important as glucose -- Role of lipids -- Multi-factoral interventions -- Ocular treatment strategies of diabetic retinopathy -- Novel therapy: Intraocular steroids -- Anti-VEGF agents -- Screening and awareness.…”
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The eye and diabetes

Table of Contents: “…Contents: Complications from diabetes -- Diabetic retinopathy -- Classification of diabetic retinopathy -- Classification of diabetic macular edema -- Clinical assessment of diabetic retinopathy -- Optical coherence tomography -- Epidemiology of diabetic retinopathy -- Strategies of diabetic retinopathy management -- Glucose control remains critical -- Blood pressure just as important as glucose -- Role of lipids -- Multi-factoral interventions -- Ocular treatment strategies of diabetic retinopathy -- Novel therapy: Intraocular steroids -- Anti-VEGF agents -- Screening and awareness.…”
Get full text
Series