Search Results - "Reductionism"

Rules and filters and their impact on success in chemical biology and drug discovery

Table of Contents: “…Contents: Academic targets and the translational gap -- Chemistry & attrition (Reductionism, genomics and high throughput screening) -- Screening diverse compounds (advantages and disadvantages) -- Medicinal chemistry (A pattern recognition discipline) -- Biology and chemistry networks analysis -- Ligand efficiency and selectivity.…”
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Rules and filters and their impact on success in chemical biology and drug discovery

Table of Contents: “…Contents: Academic targets and the translational gap -- Chemistry & attrition (Reductionism, genomics and high throughput screening) -- Screening diverse compounds (advantages and disadvantages) -- Medicinal chemistry (A pattern recognition discipline) -- Biology and chemistry networks analysis -- Ligand efficiency and selectivity.…”
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Rules and filters and their impact on success in chemical biology and drug discovery

Table of Contents: “…Contents: Academic targets and the translational gap -- Chemistry & attrition (Reductionism, genomics and high throughput screening) -- Screening diverse compounds (advantages and disadvantages) -- Medicinal chemistry (A pattern recognition discipline) -- Biology and chemistry networks analysis -- Ligand efficiency and selectivity.…”
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Descriptive vs. mechanistic biology

Table of Contents: “…Contents: History of descriptive physiology -- Systems biology -- The biota expansion -- Downward causation vs. cell-cell signaling -- Holism vs. Reductionism: philosophical views about nature -- Molecular changes mediating evolution -- Cell communication as mechanism of novelty -- From phylogeny-ontogeny to homeostasis & repair -- Homeostasis as the mechanism for evolution -- Explicate/Implicate order.…”
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On the utility of a mechanistic approach to physiology part 1: Descriptive vs. mechanistic biology /

Table of Contents: “…Contents: History of descriptive physiology -- Systems biology -- The biota expansion -- Downward causation vs. cell-cell signaling -- Holism vs. Reductionism: philosophical views about nature -- Molecular changes mediating evolution -- Cell communication as mechanism of novelty -- From phylogeny-ontogeny to homeostasis & repair -- Homeostasis as the mechanism for evolution -- Explicate/Implicate order.…”
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On the utility of a mechanistic approach to physiology part 1: Descriptive vs. mechanistic biology /

Table of Contents: “…Contents: History of descriptive physiology -- Systems biology -- The biota expansion -- Downward causation vs. cell-cell signaling -- Holism vs. Reductionism: philosophical views about nature -- Molecular changes mediating evolution -- Cell communication as mechanism of novelty -- From phylogeny-ontogeny to homeostasis & repair -- Homeostasis as the mechanism for evolution -- Explicate/Implicate order.…”
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Deciphering neurodegeneration models and methods /

Table of Contents: “…Contents: Deciphering Neurodegeneration: Models and Methods -- The challenge of neurodegeneration -- Huge diversity in cell types -- Nature versus nurture -- Reductionism versus systems biology -- Cellular models -- Yeast -- Primary cells -- Cell lines -- Stem cells -- Model organisms -- Caenorhabditis elegans -- Drosophila melanogaster -- Zebrafish -- Danio rerio -- Rodents -- Molecular biology approaches -- Knock out and knock in -- Genomic editing -- RNAi -- Overexpression -- Gene expression -- rtPCR -- Microarrays -- RNAseq -- Protein analysis -- Immunoblot -- ELISA -- Mass spec and proteomics -- Microscopy -- Immunocytochemistry -- Live cell imaging -- Electrophysiology.…”
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Deciphering neurodegeneration models and methods /

Table of Contents: “…Contents: Deciphering Neurodegeneration: Models and Methods -- The challenge of neurodegeneration -- Huge diversity in cell types -- Nature versus nurture -- Reductionism versus systems biology -- Cellular models -- Yeast -- Primary cells -- Cell lines -- Stem cells -- Model organisms -- Caenorhabditis elegans -- Drosophila melanogaster -- Zebrafish -- Danio rerio -- Rodents -- Molecular biology approaches -- Knock out and knock in -- Genomic editing -- RNAi -- Overexpression -- Gene expression -- rtPCR -- Microarrays -- RNAseq -- Protein analysis -- Immunoblot -- ELISA -- Mass spec and proteomics -- Microscopy -- Immunocytochemistry -- Live cell imaging -- Electrophysiology.…”
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Deciphering neurodegeneration models and methods /

Table of Contents: “…Contents: Deciphering Neurodegeneration: Models and Methods -- The challenge of neurodegeneration -- Huge diversity in cell types -- Nature versus nurture -- Reductionism versus systems biology -- Cellular models -- Yeast -- Primary cells -- Cell lines -- Stem cells -- Model organisms -- Caenorhabditis elegans -- Drosophila melanogaster -- Zebrafish -- Danio rerio -- Rodents -- Molecular biology approaches -- Knock out and knock in -- Genomic editing -- RNAi -- Overexpression -- Gene expression -- rtPCR -- Microarrays -- RNAseq -- Protein analysis -- Immunoblot -- ELISA -- Mass spec and proteomics -- Microscopy -- Immunocytochemistry -- Live cell imaging -- Electrophysiology.…”
Get full text
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