Search Results - "Prototype This!"
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Suggested Topics within your search.
- Treatment 2
- physiopathology 2
- therapy 2
- Alzheimer Disease 1
- Alzheimer's disease 1
- Amyloid beta-Peptides 1
- Amyloid beta-protein 1
- Anti-Bacterial Agents 1
- Arthritis, Rheumatoid 1
- Autism in children 1
- Autism spectrum disorders in children 1
- Autistic Disorder 1
- Autistic children 1
- Autonomic Pathways 1
- Bioelectronics 1
- Biological Evolution 1
- Brain 1
- Calcium 1
- Calcium Channels 1
- Calcium Signaling 1
- Cellular signal transduction 1
- Chemotherapy 1
- Child Development Disorders, Pervasive 1
- Cytokines 1
- Electric stimulation 1
- Evolution (Biology) 1
- Evolutionary genetics 1
- Family 1
- Family relationships 1
- Gene-Environment Interaction 1
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Protein kinase structure, function and regulation
Published 2010Table of Contents: “…Contents: Overview of protein kinase structure and function using PKA as a prototype for this enzyme superfamily -- What we have learned from the overall structural kinome -- Comparison of many protein kinases -- Eukaryotic protein kinase regulation -- Elucidation of general rules of architecture -- Illustration of how PKA is regulated by cAMP and how it is localized to specific macromolecular complexes through scaffold proteins.…”
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Electronic Video -
2
Diseases of civilization an evolutionary legacy /
Published 2007Table of Contents: “…Contents: There is a mismatch between what we were originally selected for and our modern environment -- The 'diseases of civilization' result from this mismatch -- Hypertension is a prototypic disease of civilization -- Many factors mediate the interaction between genes and the environment to promote hypertension.…”
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Electronic Video -
3
G-protein coupled receptors hormone membrane receptors /
Published 2007Table of Contents: “…Contents: Rhodopsin: prototype GPCR -- Major classes of GPCRs: rhodopsin-like, glucagon-like, mGlu-like -- Experimental approaches to study GPCR structure -- Rhodopsin crystal structure -- GPCR activation -- Signal trafficking -- Receptor RNA processing/isoforms -- GRKs/arrestin -- Rhodopsin dimerization -- RAMPs: receptor activity modifying protein -- RAMPs, heterodimers and expression -- GPCRs and disease -- Thyroxine and thyrotropin…”
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Electronic Video -
4
Protein networks of voltage-gated Ca2+ channels proteomic & functional analysis of local Ca2+ signalling /
Published 2013Table of Contents: “…Contents: Significance and molecular organization of local Ca2+ signalling -- Proteomic analysis of the nano-environment of voltage-gated Ca2+ (Cav) channels -- Structure and operation of the Cav2 channels from mammalian brain -- Operation of Cav-BK channel complexes -- Cav-BK complex as a prototypic Ca2+ nano-domain.…”
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Electronic Video -
5
Bioelectronic medicine immunomodulation by vagus nerve stimulation /
Published 2019Table of Contents: “…Contents: Role of the cholinergic anti-inflammatory pathway or inflammatory reflex in chronic inflammation -- How its role was discovered in a prototypic immune-mediated inflammatory disease (rheumatoid arthritis) -- Bioelectronic vagus nerve stimulation effect on cytokine production and reduction of disease activity in chronic inflammatory disease -- Opportunity to treat a wide variety of conditions using bioelectronics.…”
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Electronic Video -
6
Siblings of children with autistic spectrum disorders Part 1 /
Published 2012Table of Contents: “…Contents: Siblings of Children with Autistic Spectrum Disorders -- Age and gender of siblings Prototypes for sibling coping -- Autism and siblings stressors -- Coping with ASD in family context -- Coping influenced by child and parent characteristics -- Autistic spectrum disorders are a syndrome -- Inside the world of the autistic spectrum child -- Autism as seen by sib in different ages -- The impact of ASD on parents and siblings -- A child with an ASD is a 'life event' -- Diagnosis of autism -- The grief process -- Outcry -- Denial -- Intrusion -- Working through -- Stasis vs. chronic sorrow -- Implications for the family.…”
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Electronic Video -
7
Structure-based drug design targeting infectious disease
Published 2008Table of Contents: “…Contents: Many antibiotics inhibit the ribosome -- Intelligent engine builds perpetual pipeline -- Crystallography shows 50S is a target-of-targets -- From new X-ray crystals to new leads -- Analog(Trade Mark) -- LINKER essentials: tethering two binding features -- BOMB essentials -- MUSIC essentials: core-swapping -- QikProp: calculating drug-like properties -- Structures + Analog(Trade Mark): balanced compounds -- Case study: enhanced oxazolidinones -- Structural foundations -- Path to enhanced oxazolidinones -- Pi contributions represent key interactions -- Probing selectivity of sparsomycin -- Seeking a new lead -- Difference density map showing rib-X prototype -- Perfect match -- A minimal scaffold for lead optimization -- Minimal scaffold binds effectively in A-site -- Activity against H. influenzae -- H. influenzae activity with time evolution -- H. flu model delivers differentiable oxazolidinones -- Moderate in vivo activity measured -- Predictive model for rat oral bioavailability -- First pool of drug candidates -- Structures + predictive models = time-saving filters.…”
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Electronic Video -
8
Abeta toxicity 1
Published 2011Table of Contents: “…Contents: The amyloid plaque -- Impact of delaying onset of AD -- The amyloidocentric theory of Alzheimer's disease -- Compelling evidence for the Abeta theory of AD -- Delay onset of AD by 5 years -- The best target for a disease-modifying drug -- APP structure and domains -- Iron-export ferroxidase activity of beta-amyloid precursor protein -- Age at onset correlates with Abeta isoforms -- Activation of PS1 -- Abeta amyloid -- The mechanism of neurodegeneration -- Abeta metal binding modes -- Current working model of Abeta toxicity -- Abeta amyloid protein: current model consistent with EXAFS -- Metal-protein attenuating compound (MPAC) with moderate affinity for metals -- Clioquinol (CQ, PBT1) the prototypic MPAC -- PBT2: SAR based on rational drug design -- CQ (PBT1) vs. …”
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Series (Alzheimer disease)
Series (Drug discovery and development in the neurosciences)
Electronic Video