Search Results - "Mathematical model"

Mathematical modeling in immunology

Subjects: “…Immune response Mathematical models. 82285…”
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Augustin Cournot Economic models and rationality.

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Portfolio planning and risk management in the pharmaceutical industry 2 /

Subjects: “…Pharmaceutical industry Mathematical models. 96587…”
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Genetic drift in human evolution part 2 of 2 /

Subjects: “…Population genetics Mathematical models. 102268…”
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Genetic drift in human evolution part 1 of 2 /

Subjects: “…Population genetics Mathematical models. 102208…”
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The coalescent

Subjects: “…Population biology Mathematical models. 82977…”
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Human migration and population structure part 2 of 2 /

Subjects: “…Population genetics Mathematical models. 102256…”
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Consanguinity and genomic sharing in human evolutionary inference

Subjects: “…Population genetics Mathematical models. 102242…”
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Portfolio planning and risk management in the pharmaceutical industry part 1 of 2 /

Subjects: “…Pharmaceutical industry Mathematical models. 96501…”
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Statistical models in population genetics

Subjects: “…Population genetics Mathematical models. 98989…”
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Human migration and population structure part 1 of 2 /

Subjects: “…Population genetics Mathematical models. 102192…”
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Evolutionary dynamics in cancer control and cure

Table of Contents: “…Contents: The molecular machinery of cancer resistance -- Adaptive therapy: exploiting the cost of resistance in cancer treatment -- Evolution-based mathematical models to design trial -- Integrating adaptive therapy mathematical model into oncology -- First strike-second strike model for cancer cure.…”
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Survival analysis

Subjects: “…Survival analysis (Biometry) Mathematical models. 97369…”
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Introduction to research strategies in cell biology

Table of Contents: “…Contents: Genetic model organisms -- Light microscopy -- Fluorescence microscopy -- Structure determination -- Identification of molecular partners -- Genome engineering -- Testing mathematical modeling.…”
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Gene drive what is possible at the population level with currently-available molecular components? /

Table of Contents: “…Contents: Mathematical modeling of gene drive -- Medea -- Toxin-antidote-based underdominant systems -- Reciprocal chromosomal translocations -- Spatially-structured modeling frameworks -- Confineable homing-based gene drive systems -- Potential for invasive homing-based systems following field trials.…”
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Gene-drives and active genetics introduction to gene-drives and their implications for health and society /

Table of Contents: “…Contents: Gene drives: overview -- CRISPR/Cas9 technology -- CRISPR/Cas9 DNA break repair -- Gene-drive elements spread rapidly in a population -- Active genetics: a new field -- Gene-drive systems -- Active genetics and drive effectors -- DNA repair mechanisms -- Mathematical modeling -- Social and ethical considerations.…”
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Detection of and adjustment for selection bias in randomized controlled clinical trials

Table of Contents: “…Contents: Introduction to selection bias -- Accrual character of clinical trials -- Restricted randomization procedures -- Blinding, masking of past treatment assignments -- Impact of 3rd order selection bias on clinical trial results -- Mathematical model to detect and adjust for 3rd order selection bias -- Restricted random walk -- Maximum likelihood estimators and their properties -- Consistency and asymptotic normality -- Likelihood ratio test.…”
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Fitness and compensation

Table of Contents: “…Contents: Concept of Darwinian fitness -- Understanding the fitness impact of drug resistance -- Mathematical models -- Reversal of drug resistance in bacteria -- How to measure fitness -- The molecular epidemiology approach -- Effect of drug resistance mutations -- Environment effects on fitness measurements -- Effect of strain genetic background -- Pre-adapted strain "families" -- Biogeography of M. tuberculosis -- Compensatory evolution -- Experimental evidence -- Compensation prevents reversion to drug sensitivity -- Types of compensatory mutations -- Questions for future research -- Comparative genomics.…”
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A versatile platform for multilevel modeling of physiological systems

Table of Contents: “…Contents: Multi-level modeling -- Physiome database and mathematical modeling -- PhysioDesigner, PHML, simulator & databases -- Module and physical-quantity -- Mathematical expressions in a model -- Reuse of modules -- SBML-PHML hybrid modeling -- Template and instance framework -- Integration of time series data and morphology -- Physical-quantity assigned to time-series data -- Modeling with morphology -- Image processing for integrating morphology -- Manipulation on medical images -- Integrating morphology with Poisson differential equations (PDEs) -- Flint simulator -- Visualization by PhysioVisualizer and in 3D morphology space -- Physiome.jp and PH database -- Inter-operation and linkage among applications (Garuda).…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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