Search Results - "Huntington's disease"

Huntington's disease

Table of Contents: “…Contents: Clinical features of Huntington's Disease -- Basic pathogenic mechanisms and pathology -- Current drug therapies -- New disease modifying therapies -- Neural transplants.…”
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Biomarkers for Huntington's disease promises and challenges /

Table of Contents: “…Contents: Summary of the genetic, pathophysiology and clinical features of Huntington's disease -- Potential drug targets in development for Huntington's disease -- The importance of biomarkers in Huntington's disease -- Current biomarkers in development in Huntington's disease.…”
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The molecular biology of Huntington's disease

Subjects: “…Huntington's disease. 90221…”
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Huntington's disease and HD-like disorders

Table of Contents: “…Contents: Huntington's disease -- Huntington's disease like disorders -- Chorea -- Anticipation -- Pathobiology of Huntington's disease -- Huntingtin protein misfolding -- Aggregation -- Ubiquitous expression including in peripheral tissues -- Juvenile Huntington's disease/Westphal variant -- Psychiatric, behavioural and cognitive symptomatology -- HD phenocopies -- C9Orf72 and SCA17.…”
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Primary and stem cell transplantation for functional repair of striatal degeneration in Parkinson's and Huntington's disease

Table of Contents: “…Contents: Neural transplantation of primary fetal tissue and stem cells -- Parkinson's and Huntington's disease -- Dopaminergic and medium spiny neurons -- Results of clinical trials -- Pre-clinical testing in rodent models of disease.…”
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Cell replacement therapy for neurodegenerative diseases

Table of Contents: “…Contents: Parkinson's Disease and therapies available -- Preclinical data supporting cell therapies for Parkinson's -- Clinical data on fetal transplant trials in Parkinson's -- Development of stem cell-derived dopamine neurons -- Huntington's Disease and therapies available -- Preclinical data supporting cell therapies for Huntington's -- Clinical data on fetal transplant trials in Huntington's -- Development of stem cell-derived medium spiny neurons.…”
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Autosomal dominant inheritance

Table of Contents: “…Contents: Autosomal dominant disorders -- Genetics -- Inheritance -- Genetic disorders -- Osteogenesis imperfecta -- RASopathies -- Huntington disease -- Penetrance -- De novo mutations.…”
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RNAi for neurological diseases

Table of Contents: “…Contents: Repeat expansion diseases -- Polyglutamine (polyQ) repeat diseases -- Huntington's disease -- Vectors for delivering genetic material to brain -- AAVs for delivering RNAi for reducing gene expression -- Artificial miRNAs -- Testing miHD for efficacy -- Off-target silencing -- MRI-guided delivery of AAV into primates -- HTT suppression -- Other gain-of function diseases -- Targeted infusion for broad coverage -- Silencing ataxin-1 -- Nonallele specific silencing: experimental design -- Expression and activity of miSCA1.…”
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Series (RNA interference)
Series (Gene transfer and gene therapy)

Challenges in genetic testing

Table of Contents: “…Contents: Genetic testing -- Ethical issues -- Clinical scenarios of genetic testing -- Lynch Syndrome -- Huntington's Disease -- EOFAD -- Indirect genetic testing -- Genetics counselling.…”
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Microsatellite and trinucleotide repeat expansion diseases

Table of Contents: “…Contents: Mendelian neurodegenerative diseases are caused by repeat expansions -- The mutation can result in gain-of-function or loss-of-function -- Fragile X syndrome -- Myotonic dystrophy -- Huntington's disease -- Friedrich's ataxia -- C9orf72.…”
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Roles for Hsp40 molecular chaperones in protein misfolding disease

Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
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Neuropathology of neurodegenerative disorders

Table of Contents: “…Contents: Current neuropathological diagnostic criteria for neurodegenerative disorders -- Major macroscopic and microscopic features -- Pattern and extent of brain atrophy -- Alzheimer's disease -- Lewy body diseases -- Frontotemporal dementia -- Other tauopathies -- Huntington's disease -- Motor Neurone Disease.…”
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Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Spectrum of mitochondrial diseases -- Mitochondrial metabolic pathway -- MtDNA mutations and disease -- Pathological features -- MELAS -- Genetic epidemiology of mtDNA mutations -- Structural components of respiratory chain complexes -- Mitochondrial DNA metabolism -- Mitochondrial proteins and oxidative phosphorylation -- Fatal mtDNA depletion syndrome -- POLG mutations -- Environmental influences on PD causation -- PARK genes -- Huntington's disease and mtDNA mutations -- Genetic basis of Friedreich's ataxia -- Mitochondrial toxins.…”
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Series (Mitochondrial biogenesis)
Series (Neurodegenerative diseases)

Protein aggregation, metals and oxidative stress in neurodegenerative diseases

Table of Contents: “…Contents: Introduction to protein conformational brain diseases -- Alzheimer's disease, A-beta and tau -- A-beta oligomers and toxicity -- A-beta generates hydrogen peroxide -- Results from experiments using electron spin resonance spectroscopy -- Parkinson's disease -- Generation of hydrogen peroxide from alpha synuclein, toxic fragments of the prion protein and the familial British dementia peptide -- Early oligomers appear to generate hydrogen peroxide -- Huntington's disease -- Protein aggregates could be protective -- Potential common toxic pathway for these brain diseases.…”
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