Search Results - "Alcoholism"

Alcoholic liver disease

Table of Contents: “…Contents: Alcoholism, including the toll of alcoholism, is key to understanding alcoholic liver disease (ALD) -- Alcoholism is clandestine disorder -- Abstinence is key to recovery from both alcoholism and ALD -- There are few evidence-based therapies for ALD, other than abstinence -- Liver transplantation is valuable in selected subjects with ALD.…”
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Alcoholic liver disease

Table of Contents: “…Contents: Alcoholism, including the toll of alcoholism, is key to understanding alcoholic liver disease (ALD) -- Alcoholism is clandestine disorder -- Abstinence is key to recovery from both alcoholism and ALD -- There are few evidence-based therapies for ALD, other than abstinence -- Liver transplantation is valuable in selected subjects with ALD.…”
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Alcoholic liver disease

Table of Contents: “…Contents: Alcoholism, including the toll of alcoholism, is key to understanding alcoholic liver disease (ALD) -- Alcoholism is clandestine disorder -- Abstinence is key to recovery from both alcoholism and ALD -- There are few evidence-based therapies for ALD, other than abstinence -- Liver transplantation is valuable in selected subjects with ALD.…”
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NASH evaluation and treatment /

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NASH evaluation and treatment /

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NASH evaluation and treatment /

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Advances in the treatment of NASH

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Advances in the treatment of NASH

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Advances in the treatment of NASH

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Immunotherapy of hepatocellular carcinoma

Table of Contents: “…Contents: Hepatocellular carcinoma (HCC) background and overview -- Non-alcoholic steatohepatitis (NASH) and HCC -- Immune suppressor mechanisms in tumour environments -- Ongoing and future immunotherapy trials in HCC.…”
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Immunotherapy of hepatocellular carcinoma

Table of Contents: “…Contents: Hepatocellular carcinoma (HCC) background and overview -- Non-alcoholic steatohepatitis (NASH) and HCC -- Immune suppressor mechanisms in tumour environments -- Ongoing and future immunotherapy trials in HCC.…”
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Immunotherapy of hepatocellular carcinoma

Table of Contents: “…Contents: Hepatocellular carcinoma (HCC) background and overview -- Non-alcoholic steatohepatitis (NASH) and HCC -- Immune suppressor mechanisms in tumour environments -- Ongoing and future immunotherapy trials in HCC.…”
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Non-P450 oxidative metabolism characteristics and drug substrates /

Table of Contents: “…Contents: Non-P450 cytosolic and mitochondrial enzymes catalysing drug oxidation -- Aldehyde oxidase and xanthine oxidase -- Alcohol dehydrogenase and aldehyde dehydrogenase -- Monoamine oxidase -- Flavin monooxygenase -- Substrate specificities -- Drug and xenobiotic substrates -- Catalytic mechanism and metabolite formation -- Reactive oxygen species -- Factors affecting enzyme activity -- Polymorphism and isozymes -- Relative importance in drug metabolism.…”
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Non-P450 oxidative metabolism characteristics and drug substrates /

Table of Contents: “…Contents: Non-P450 cytosolic and mitochondrial enzymes catalysing drug oxidation -- Aldehyde oxidase and xanthine oxidase -- Alcohol dehydrogenase and aldehyde dehydrogenase -- Monoamine oxidase -- Flavin monooxygenase -- Substrate specificities -- Drug and xenobiotic substrates -- Catalytic mechanism and metabolite formation -- Reactive oxygen species -- Factors affecting enzyme activity -- Polymorphism and isozymes -- Relative importance in drug metabolism.…”
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Non-P450 oxidative metabolism characteristics and drug substrates /

Table of Contents: “…Contents: Non-P450 cytosolic and mitochondrial enzymes catalysing drug oxidation -- Aldehyde oxidase and xanthine oxidase -- Alcohol dehydrogenase and aldehyde dehydrogenase -- Monoamine oxidase -- Flavin monooxygenase -- Substrate specificities -- Drug and xenobiotic substrates -- Catalytic mechanism and metabolite formation -- Reactive oxygen species -- Factors affecting enzyme activity -- Polymorphism and isozymes -- Relative importance in drug metabolism.…”
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Pancreatitis and Ca2+ signalling

Table of Contents: “…Contents: Normal Calcium signaling events in pancreatic acinar cells -- Hyperstimulation as a cause of sustained global elevation of the cytosolic [Calcium], Calcium-dependent vacuolization and Calcium-dependent protease activation -- Bile acids causing sustained global Calcium signals and necrosis -- Calcium-dependent necrosis evoked by non-oxidative alcohol metabolites (fatty acid ethyl esters and fatty acids) but not by alcohol or acetaldehyde -- The mechanism of action of fatty acid ethyl esters and fatty acids -- The mildly protective effect of coffee (caffeine) -- A model for the initiation of alcoholic pancreatitis.…”
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Series (Calcium signaling I)
Series (Calcium signaling II)

Pancreatitis and Ca2+ signalling

Table of Contents: “…Contents: Normal Calcium signaling events in pancreatic acinar cells -- Hyperstimulation as a cause of sustained global elevation of the cytosolic [Calcium], Calcium-dependent vacuolization and Calcium-dependent protease activation -- Bile acids causing sustained global Calcium signals and necrosis -- Calcium-dependent necrosis evoked by non-oxidative alcohol metabolites (fatty acid ethyl esters and fatty acids) but not by alcohol or acetaldehyde -- The mechanism of action of fatty acid ethyl esters and fatty acids -- The mildly protective effect of coffee (caffeine) -- A model for the initiation of alcoholic pancreatitis.…”
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Series (Calcium signaling I)
Series (Calcium signaling II)

Pancreatitis and Ca2+ signalling

Table of Contents: “…Contents: Normal Calcium signaling events in pancreatic acinar cells -- Hyperstimulation as a cause of sustained global elevation of the cytosolic [Calcium], Calcium-dependent vacuolization and Calcium-dependent protease activation -- Bile acids causing sustained global Calcium signals and necrosis -- Calcium-dependent necrosis evoked by non-oxidative alcohol metabolites (fatty acid ethyl esters and fatty acids) but not by alcohol or acetaldehyde -- The mechanism of action of fatty acid ethyl esters and fatty acids -- The mildly protective effect of coffee (caffeine) -- A model for the initiation of alcoholic pancreatitis.…”
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Series (Calcium signaling I)
Series (Calcium signaling II)

Drug metabolism in liver disease

Table of Contents: “…Contents: Liver disease and drug clearance - Mechanistic explanations - Intact hepatocyte hypothesis - Sick cell theory - Sequential progressive model of liver disease - Viral liver disease - Alcoholic liver disease - Hepatocellular carcinoma - Liver transplantation…”
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Drug metabolism in liver disease

Table of Contents: “…Contents: Liver disease and drug clearance - Mechanistic explanations - Intact hepatocyte hypothesis - Sick cell theory - Sequential progressive model of liver disease - Viral liver disease - Alcoholic liver disease - Hepatocellular carcinoma - Liver transplantation…”
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