The blood-retinal barrier

Table of Contents: “…Contents: Two major components for the blood-retinal barrier -- Blood-ocular barriers and main fluid movements -- Tight-junctions in retinal vessels -- Inner blood-retinal barrier -- Outer blood-retinal barrier -- Transport mechanisms -- The concept of cell polarity at the BRB -- Major types of transport mechanisms -- Clinical evaluation of the BRB -- Alteration of the BRB in retinal disease -- Diabetic macular edema -- BRB and treatments of retinal diseases.…”
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The blood-retinal barrier

Table of Contents: “…Contents: Two major components for the blood-retinal barrier -- Blood-ocular barriers and main fluid movements -- Tight-junctions in retinal vessels -- Inner blood-retinal barrier -- Outer blood-retinal barrier -- Transport mechanisms -- The concept of cell polarity at the BRB -- Major types of transport mechanisms -- Clinical evaluation of the BRB -- Alteration of the BRB in retinal disease -- Diabetic macular edema -- BRB and treatments of retinal diseases.…”
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Factor IX

Table of Contents: “…Contents: Factor IX -- Blood coagulation -- Thrombus formation -- Factor IX gene -- Vitamin Kdependent proteins and gamma-carboxyglutamic acid -- Factor IX: biochemistry and structure -- Hemophilia B.…”
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Barrier mechanisms in the developing brain mechanisms and misunderstandings /

Table of Contents: “…Contents: The brain barriers -- Historical perspective -- Morphology of cerebral blood vessels and choroid plexus in the development brain -- Are tight junctions functionally tight? …”
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Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

Table of Contents: “…Contents: The blood-brain barrier is not just a static wall, but "a cerebral clearance organ" -- The BBB multiple efflux transporters play a part in CNS detoxification by pumping out endogenous compounds from the brain -- Neurotransmitters -- Neuromodulators -- Metabolites of neurotransmitters -- Uremic toxins -- Cholesterol metabolites.…”
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Brain-to-blood efflux transport of endogenous compounds and its analogue drug at the blood-brain barrier

Table of Contents: “…Contents: The blood-brain barrier is not just a static wall, but "a cerebral clearance organ" -- The BBB multiple efflux transporters play a part in CNS detoxification by pumping out endogenous compounds from the brain -- Neurotransmitters -- Neuromodulators -- Metabolites of neurotransmitters -- Uremic toxins -- Cholesterol metabolites.…”
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Vasoactive peptides and the blood-brain barrier

Table of Contents: “…Contents: Blood-brain-barrier (BBB) functions, permeability pathways and transporters modulated by vasoactive peptides -- The BBB as a source and target of vasocative peptides -- Angiotensins -- Bradykinin -- Adrenomedullin -- Calcitonin-gene related peptide -- Endothelins -- Natriuretic peptides -- Pituitary adenylate cyclase activating peptide -- Substance P -- Urotensin -- Vasopressin -- Potential use of vasocative peptides as modulators of BBB functions.…”
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Glucose transport across the blood-brain barrier

Table of Contents: “…Contents: Functions of the neurovascular unit -- Brain energy substrates -- Pathways across the blood-brain barrier -- Glucose utilization and transport -- Glucose uniporters -- Kinetic transport parameters -- Glucose transport in baseline and during activation -- Neurovascular coupling -- Neurometabolic coupling -- Neurobarrier coupling -- Dynamic changes of glucose concentration -- GLUT-1 stimulation in vitro and in vivo -- Roadmaps for glucose from blood to neurons.…”
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The blood-brain barrier and CNS drug development

Table of Contents: “…Contents: Restrictive nature of the blood-brain barrier -- Non-vascular routes for brain drug delivery -- Vascular routes for brain drug delivery -- Concept of Trojan horses -- Discovery of novel receptor-mediated transcytosis routes across the blood-brain barrier -- Principles of blood-brain barrier vector development in experimental models.…”
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In vitro models of the blood-brain barrier

Table of Contents: “…Contents: Blood-brain barrier -- In vitro models of blood-brain barrier -- Blood-brain barrier permeability -- Brain endothelium and tight junctions -- Transporters at the blood-brain barrier.…”
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Cellular composition of the blood-brain barrier (BBB)

Table of Contents: “…Contents: Sites of CNS barriers -- Neurovascular unit -- Blood-brain barrier (BBB) at brain capillary endothelium -- Functions of BBB -- Tight junctions -- Pathways across the BBB -- BBB biomarkers -- Supporting cell types -- Astrocytes and BBB induction -- Pericytes -- Microglia -- Mast cells -- Smooth muscle -- BBB modulation -- Heterogeneity -- Changes in pathology.…”
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In vivo systems

Subjects: “…Blood-Brain Barrier.…”
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Barrier mechanisms in the developing brain mechanisms and misunderstandings /

Table of Contents: “…Contents: The brain barriers -- Historical perspective -- Morphology of cerebral blood vessels and choroid plexus in the development brain -- Are tight junctions functionally tight? …”
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Measuring blood pressure in small animal patients

Table of Contents: “…Contents: Signs that you should measure blood pressure in small animal patients -- Hypertension in small animal practice, and its association with endocrine and renal diseases -- Targets of hypertension -- The pros and cons of Doppler and Oscillometric blood pressure monitors -- The benefits of observing oscillometric tracing -- The impact of white coat effect on blood pressure and how to minimize it.…”
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Barrier mechanisms in the developing brain protection or vulnerability? /

Table of Contents: “…Contents: The brain develops within a well-defined internal environment -- The properties of this internal environment are determined by transporters in the cellular interfaces between the blood, brain and cerebrospinal fluid -- The transporters are effective because the intercellular spaces between the cells in the interfaces are sealed by tight junctions -- The transporters are both influx and efflux and many are active very early in brain development -- Although brain barrier mechanisms are present very early in development they are vulnerable to pathological conditions e.g. inflammation, which may result in barrier dysfunction and damage to the fragile developing brain -- These mechanisms thus provide protection and a stable internal environment, but some may render the developing brain more vulnerable e. g. inward transport of toxins such as mercury via a normal amino acid transporter.…”
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Factor IX

Table of Contents: “…Contents: Factor IX -- Blood coagulation -- Thrombus formation -- Factor IX gene -- Vitamin Kdependent proteins and gamma-carboxyglutamic acid -- Factor IX: biochemistry and structure -- Hemophilia B.…”
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Tissue factor and factor VII initiation of blood coagulation /

Table of Contents: “…Contents: Tissue factor and factor VII -- Initiation of blood coagulation -- Vertebrate blood coagulation -- The resting state -- The procoagulant response -- The anticoagulant response -- Molecular pathology -- Tissue factor -- Factor VII -- Tissue factor pathway inhibitor.…”
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Coagulation in sepsis

Subjects: “…Blood coagulation factors.…”
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Factor VIII and Haemophilia A

Table of Contents: “…Contents: Normal blood coagulation -- What is haemophilia A? -- Different types of factor VIII gene mutations -- Loss of protein or loss of function -- Structural interpretation of protein dysfunction -- Other rare causes of FVIII deficiency.…”
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Ingestive peptides

Table of Contents: “…Contents: Ingestive peptides -- Transport across the blood-brain barrier -- Relation to obesity -- Control of transporter and implications for body weight control -- Ghrelin and its relation to the blood-brain barrier and body weight control.…”
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