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Imputation in genome-wide association analysis

Table of Contents: “…Contents: The general problem of imputation -- Testing imputed SNPs for association -- Examples of imputation in the WTCCC -- Properties of imputation (LD, populations, chips, allele frequency) -- Using imputed data for meta-analysis -- The Strand Issue and Imputation QC metrics -- The 1000 Genomes Project -- Pre-phasing and haplotype estimation -- The Haplotype Reference Consortium.…”
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Development of immunotherapies for type 1 diabetes value and limitations of mouse models /

Table of Contents: “…Contents: The use of animal models -- Strategy T1D: a prioritization process from mice to humans -- The non-obese diabetic (NOD) mouse model: reproducibility, increasing stringency level options, predictive potential of biomarkers -- Alternate models: The RIP-LCMV mouse -- Ongoing general challenges, mitigation actions & consequences.…”
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Development of immunotherapies for type 1 diabetes value and limitations of mouse models /

Table of Contents: “…Contents: The use of animal models -- Strategy T1D: a prioritization process from mice to humans -- The non-obese diabetic (NOD) mouse model: reproducibility, increasing stringency level options, predictive potential of biomarkers -- Alternate models: The RIP-LCMV mouse -- Ongoing general challenges, mitigation actions & consequences.…”
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Imputation in genome-wide association analysis

Table of Contents: “…Contents: The general problem of imputation -- Testing imputed SNPs for association -- Examples of imputation in the WTCCC -- Properties of imputation (LD, populations, chips, allele frequency) -- Using imputed data for meta-analysis -- The Strand Issue and Imputation QC metrics -- The 1000 Genomes Project -- Pre-phasing and haplotype estimation -- The Haplotype Reference Consortium.…”
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Series (Statistical methods for the analysis of genome-wide association studies)
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Organic synthesis the disconnection approach / by Warren, Stuart G.

Table of Contents: “…The disconnection approach -- Basic principles : synthons and reagents synthesis of aromatic compounds -- Strategy I : the order of events -- One-group C-X disconnections -- Strategy II : chemoselectivity -- Two-group C-X disconnections -- Strategy III : reversal of polarity, cyclisations, summary of strategy -- Amine synthesis -- Strategy IV : protecting groups -- One group C-C disconnections I : alcohols -- General strategy A : choosing a disconnection -- Strategy V : stereoselectivity A -- One group C-C disconnections II : carbonyl compounds -- Strategy VI : regioselectivity -- Alkene synthesis -- Strategy VII : use of acetylenes (alkines) -- Two-group C-C disconnections I : Diels-Alder reactions -- Strategy VIII : introduction to carbonyl condensations -- Two-group C-C disconnections II : 1,3-difunctionalised compounds -- Strategy IX : control in carbonyl condensations -- Two-group C-C disconnections : 1,5-difunctionalised compounds -- Strategy X : aliphatic nitro compounds in synthesis -- Two-group disconnections IV : 1,2-difunctionalised compounds -- Strategy XI : radical reactions in synthesis -- Two-group disconnection V : 1,4-difunctionalised compounds -- Strategy XII : reconnection -- Two-group C-C disconnections VI : 1,6-diCarbonyl compounds -- General strategy B : strategy of carbonyl disconnections -- Strategy XIII : introduction to ring synthesis : saturated heterocycles -- Three-membered rings -- Strategy XIV : rearrangements in synthesis -- Four-membered rings : photochemistry in synthesis -- Strategy XV : the use of ketenes in synthesis -- Five-membered rings -- Strategy XVI : pericyclic reactions in synthesis : special methods for five-membered rings -- Six-membered rings -- General strategy C : strategy of ring synthesis -- Strategy XVII : stereoselectivity B -- Aromatic heterocycles -- General strategy D : advanced strategy.…”
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Linear transformation : examples and solutions / by Shah, Nita H., Chaudhari, Urmila B.

Table of Contents: “…1.3.4 Contraction and Dilation Operators -- 1.3.5 Shear Operator -- 1.4 Composition of Two or More Transformations -- Exercise Set 1 -- Answers to Exercise Set 1 -- Chapter 2 General Linear Transformations -- 2.1 Introduction of General Linear Transformations -- 2.1.1 Properties of Linear Transformations -- 2.2 Forming a Linear Transformation -- 2.2.1 Obtaining Linear Transformations from Basis Vectors and their Image Vectors -- 2.3 Kernel and Range of Linear Transformation T -- 2.4 Composition of the Linear Transformation -- Exercise Set 2 -- Answers to Exercise Set 2…”
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Destruction of hazardous chemicals in the laboratory by Lunn, George

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Lupus the essential clinician's guide / by Wallace, Daniel J. (Daniel Jeffrey), 1949-

Table of Contents: “…History of lupus -- Definitions and classification -- Epidemiology -- Pathogenesis -- Clinical findings-symptoms and signs -- Laboratory and imaging correlates -- Differential diagnosis and disease associations -- Important subsets -- Methods of ascertainment used for clinical trials -- General concepts of treatment -- Medications used to manage lupus -- Economic impact and disability issues -- Prognosis -- Experimental and innovative therapies.…”
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Punched-card systems and the early information explosion, 1880-1945 by Heide, Lars, 1950-

Table of Contents: “…Punched cards and the 1890 United States census -- New users, new machines -- U.S. challengers to Hollerith -- The rise of international business machines -- Decline of punched cards for European census processing -- Punched cards for general statistics in Europe -- Different roads to European punched-card bookkeeping -- Keeping tabs on society with punched cards.…”
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Significant changes to the wind load provisions of ASCE 7-10 an illustrated guide / by Stafford, T. Eric

Table of Contents: “…Reorganization -- pt. 2. General requirements for determining wind loads -- pt. 3. …”
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Comparative semitic linguistics a manual / by Bennett, Patrick R.

Table of Contents: “…Basics of descriptive linguistics -- pt. 2. A general introduction to the semitic language family -- pt. 3. …”
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Mobility models for next generation wireless networks ad hoc, vehicular, and mesh networks / by Santi, Paolo

Table of Contents: “…Introduction -- pt. 2. "General-purpose" mobility models -- pt. 3. Mobility models for WLAN and mesh networks -- pt. 4. …”
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The headaches /

Table of Contents: “…section I. General aspects of the headaches -- section II. Basic science aspects of the headaches -- section III. …”
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Punched-Card Systems and the Early Information Explosion, 1880–1945 by Heide, Lars, 1950-

Table of Contents: “…Punched cards and the 1890 United States census -- New users, new machines -- U.S. challengers to Hollerith -- The rise of international business machines -- Decline of punched cards for European census processing -- Punched cards for general statistics in Europe -- Different roads to European punched-card bookkeeping -- Keeping tabs on society with punched cards.…”
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Complement and T cells

Table of Contents: “…Contents: Complement in the regulation of general immune cell activity -- Indirect (APC-mediated) effects of complement on T cell activation -- Direct effects of complement on T cell responses -- Role of autocrine and intracellular complement (the Complosome) in Th1 responses -- Crosstalk between the NLRP3 inflammasome and the Complosome -- Regulation of cell metabolism by intracellular/autocrine complement.…”
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Genetics of Hereditary Spastic Paraplegia

Table of Contents: “…Contents: Definition and overview of Hereditary spastic paraplegia (HSP) -- The motor system in HSP -- HSP pathophysiology HSP -- Heterogeneity of HSP -- Neuropathology in HSP -- Clinical features & classification -- Diagnosis and treatment -- Genetics: general features -- Timeline of HSP genetic discoveries -- Autosomal dominant and recessive inheritance & genes -- X-linked genes -- Pathogenic mechanisms.…”
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Behavior intervention and autism

Table of Contents: “…-- Positive behavior support -- Communication and behavior -- General issues regarding problem behaviors -- Why conduct a functional analysis? …”
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Complement and T cells

Table of Contents: “…Contents: Complement in the regulation of general immune cell activity -- Indirect (APC-mediated) effects of complement on T cell activation -- Direct effects of complement on T cell responses -- Role of autocrine and intracellular complement (the Complosome) in Th1 responses -- Crosstalk between the NLRP3 inflammasome and the Complosome -- Regulation of cell metabolism by intracellular/autocrine complement.…”
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Genetics of Hereditary Spastic Paraplegia

Table of Contents: “…Contents: Definition and overview of Hereditary spastic paraplegia (HSP) -- The motor system in HSP -- HSP pathophysiology HSP -- Heterogeneity of HSP -- Neuropathology in HSP -- Clinical features & classification -- Diagnosis and treatment -- Genetics: general features -- Timeline of HSP genetic discoveries -- Autosomal dominant and recessive inheritance & genes -- X-linked genes -- Pathogenic mechanisms.…”
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Behavior intervention and autism

Table of Contents: “…-- Positive behavior support -- Communication and behavior -- General issues regarding problem behaviors -- Why conduct a functional analysis? …”
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