Search Results - Genomics PLC~
Suggested Topics within your search.
Suggested Topics within your search.
- Cell Cycle 5
- genetics 5
- Genes, cdc 4
- metabolism 3
- Cancer 2
- Genetic aspects 2
- Genetic transcription 2
- Mitochondria 2
- Transcription Factors 2
- Transcription, Genetic 2
- immunology 2
- physiology 2
- BIOGRAPHY & AUTOBIOGRAPHY 1
- Biotechnologie dans la litterature 1
- Biotechnology in literature 1
- CDC2 Protein Kinase 1
- Cell Cycle Checkpoints 1
- Cell Cycle Proteins 1
- Cell Nucleus 1
- Cell Transformation, Neoplastic 1
- Cell cycle 1
- Cell nuclei 1
- Chromatin 1
- Chromosomal proteins 1
- Colon (Anatomy) 1
- Colorectal Neoplasms 1
- DNA 1
- DNA Damage 1
- DNA Methylation 1
- DNA Mismatch Repair 1
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Spindle movement and checkpoint control during mitosis in yeast
Published 2009Get full text
Series
Electronic Video -
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Biopunk Dystopias : Genetic Engineering, Society and Science Fiction /
Published 2016Full text available:
Electronic eBook -
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Replication licensing
Published 2009Table of Contents: “…Contents: Problems in ensuring complete genome replication -- Experiments revealing the existence of a replication licence -- The licensing reaction -- ORC, Cdc6, Cdt1 and Mcm2-7 -- Cell cycle regulation of licensing -- Pre-RC substrates in yeast -- Regulation of licensing in animal cells by Cdt1 degradation and geminin inhibition -- Is there a licensing checkpoint? …”
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Systems biology of the cell cycle
Published 2014Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Electronic Video -
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Colorectal cancer and the rare variant hypothesis
Published 2020Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Electronic Video -
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Immune-mediated liver disease
Published 2011Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Electronic Video -
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Nuclear control of respiratory chain expression by transcriptional activators and coactivators
Published 2007Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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Series
Electronic Video -
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Nuclear control of electron transport chain gene expression
Published 2019Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
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Bacterial extrachromosomal elements role in chemical detoxification and potential cancer therapy /
Published 2008Table of Contents: “…Contents: Examples of degradative plasmids -- Xylene and toluene degradation by TOL plasmids -- The chloro-catechol orthocleavage pathway -- Catabolic pathways/genes in 2,4-D degradation -- Chemostatic evolution of 2,4,5-T degradative genes -- Unusual genomic structure of the 2,4,5-T genes -- Sequence characteristics of the clc element -- Evolution of s-triazine degradative plasmids -- Azurin interaction with different targets -- Structural features of azurin and immunoglobulins -- Secretion of azurin upon exposure to cancer cells -- Sequences in released extrachromosomal DNA -- Released CpG-rich DNA has anti-tumor activity.…”
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Electronic Video -
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Innate immunity in the intestine in health and disease
Published 2013Table of Contents: “…Contents: Mucosal tissues of the human body -- Intestinal pathogens -- Mucosal immune system: distinctive features -- Gut-associated lymphoid tissue (GALT) -- Structure of the GALT: small and large intestine -- Mucus, a key protective barrier -- Antimicrobial proteins protect the epithelium -- Epithelial cell transcytosis of secretory IgA -- Uptake and transport of antigen by M cells -- Microbial sensing regulates intestinal homeostasis -- Sensing of microbes occurs through PRR -- MyD88 signals in IEC -- Intestinal macrophages are anti-inflammatory -- Intestinal DC 'conditioning' -- Inflammatory bowel disease (IBD) -- Genome-wide association studies -- The enigma of NOD2 and Crohn's disease -- NOD2 signaling in response to bacterial MDP -- NOD2 signaling regulates myeloid cell function -- Autophagy also regulates IEC and myeloid cells -- MyD88 activation drives intestinal inflammation -- Haematopoeitic MyD88 signals -- Immune dysregulation in chronic inflammation -- Innate lymphoid cells (ILC) drive innate IBD -- Leukocyte populations and intestinal homeostasis.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases
Published 2014Get full text
Series
Electronic Video