Search Results - Drugs

The Long War on Drugs /

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Of genes and drugs genetic determinants of adverse drug reactions /

Table of Contents: “…Contents: Type A and B Adverse Drug Reactions (ADRs) -- Pharmacokineticpharmacodynamic paradigm -- ADME framework -- Mechanisms of ADRs -- Pharmacogenetics and pharmacogenomics -- Polygenic traits -- Environmental factors -- Phenotype and endophenotype -- Candidate genes -- Association and linkage disequilibrium.…”
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Psychotropic drugs

Table of Contents: “…Contents: Discovering psychotropic drugs -- Psychotropic drugs: basic mechanisms of action.…”
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Drug development from discovery to manufacture /

Table of Contents: “…Contents: Drug safety -- Drug efficacy -- Research and development -- Drug discovery -- Preclinical research -- Clinical trials.…”
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New drugs for asthma

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Series (Periodic reports)
Series (Advances in asthma)

New drugs for asthma

Table of Contents: “…Contents: Improvements in existing therapies have been the main approach -- New classes of drug in development -- Upcoming oral and inhaled therapies that target inflammation in asthma -- Patients with severe disease -- Inflammation in severe asthma is usually corticosteroid insensitive.…”
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Current drugs for TB treatment

Table of Contents: “…Contents: Historical perspective -- Timeframe for drug and regimen development -- Current regimens -- Current WHO and ATS guidelines -- Treatment principles -- Pathological basis of action of TB drugs -- Drug profiles -- Limitations of current treatment regimens & special situations -- Problems with first line therapy -- Brief consideration of drug resistance.…”
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Antiviral drugs (non-HIV)

Table of Contents: “…Contents: Why do we need antiviral drugs? -- Overview of approved antiviral drugs -- Antiviral targets mechanisms and resistance -- Hepatitis C virus: biology and current drugs -- Hepatitis B virus: biology and treatments -- Herpesvirus drugs -- Influenza virus: approved drugs -- Broad-spectrum antivirals -- Diseases for which we need antivirals.…”
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Narkomania : Drugs, HIV, and Citizenship in Ukraine / by Carroll, Jennifer J., 1981-

Table of Contents: “…Homegrown -- What counts when you're counting -- A deficit of desire -- Star wars and the state -- Drugs of revolution -- Sovereignty and abandonment.…”
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Where did drugs come from?

Table of Contents: “…Contents: Drug discovery strategies -- How drugs were discovered -- The paradox between empirical and hypothesis driven drug discovery -- How drugs work/molecular mechanism of action is at the core of the paradox -- Practical application of new knowledge.…”
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Anti-seizure drugs discovery and development /

Table of Contents: “…Contents: Seizures and epilepsy -- Drugs for the symptomatic treatment of seizures -- Finding new Anti-Seizure Drugs is a combination of serendipity, screening and rational approaches -- Drug Development -- Preclinical studies -- Controlled Clinical Trials are needed to prove that an anti-seizure drug is effective.…”
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Series (Drug discovery)

CNS drug design

Table of Contents: “…Contents: Central nervous system diseases -- Drug market for CNS disorders -- Traditional CNS drug targets -- Novel CNS drug targets -- Multiple obstacles for drug delivery to CNS -- Pathways for drug exchange within the CNS -- The structure of brain capillaries impedes uptake -- Measures of drug uptake and distribution in brain -- BBB permeability and solute lipid solubility -- Tissues capillary PS and 95 per cent equilibration time -- Cerebral blood flow affects drug uptake and Kin -- Initial uptake vs. steady-state distribution -- Plasma protein binding and brain drug uptake -- Brain capillary drug transporters -- Transporters and drug distribution across BBB -- "Enzymatic" blood-brain barrier -- Relation between bound and free drug -- Free drug distribution ratio at steady state -- BBB changes in pathology and disease -- Drug-like properties to cross the BBB -- Early findings in BBB drug uptake -- Measures of lipophilicity -- Passive permeability across lipid membranes -- Drug ionization -- Influence of pH on neutral fraction -- Lipinski "rule of five" -- Impact of hydrogen bonds and alkyl groups -- Positive CNS drugs -- Poor CNS drug -- in vitro measures -- In vivo measures -- Methods to improve brain uptake -- Simple rules for efflux transporters -- % drug distribution to brain -- Biologic compounds -- Brain pharmacokinetics.…”
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Series (Blood-brain barrier)
Series (Small molecule drug discovery)

Spinal drug delivery technology, biology and toxicology /

Table of Contents: “…Contents: Pain: concepts and early anatomy -- Role of sensory nerves and spinal cord -- Enabling technology for spinal anesthesia -- Rapid evolution of spinal anesthetic delivery in the US -- Early appreciation of risks of spinal anesthesia -- Modulation of spinal processing -- Targeting drugs at spinal function -- Other systems which regulate spinal afferent transmission -- Pain selectively diminished by spinal opioids -- Spinal mu/delta opioid action -- Spinal analgesics: animal and human pain -- Safety of spinal drugs -- Early safety issues with spinal anesthetic -- Classes of spinal toxicity -- Intrathecal lidocaine and toxicity -- Spinal toxicity: root, parenchyma, meningeal -- Human intrathecal morphine: granuloma -- IT morphine and granulomas concentration vs. dose -- Future and neuraxial drug delivery.…”
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Drug resistant tuberculosis biology, epidemiology and control /

Table of Contents: “…Contents: Natural history and epidemiology of TB -- Discovery of antibiotics -- Drug combinations as used in TB control programmes worldwide -- How drug resistance arises -- Geographical distribution of drug-resistant TB -- TB drug resistance and HIV/AIDS -- Reversing the spread of drug-resistant TB.…”
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Antiretroviral drug resistance

Table of Contents: “…Contents: HIV replication and biological basis of drug resistance -- Antiviral drugs -- Emergence of drug resistance in practice -- Measurement of drug resistance.…”
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Prodrugs and drug delivery

Table of Contents: “…Contents: Prodrugs and drug delivery -- Prodrug concept and designing prodrugs -- Solving ADMET properties -- Prevalence, recent approvals and best-sellers.…”
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Enzymology in drug discovery part 1 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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Enzymology in drug discovery part 2 of 2 /

Table of Contents: “…Contents: Enzymes as targets for drug discovery -- Protein-ligand binding equilibria -- Enzyme reaction mechanisms -- Structure and function of enzyme active sites -- Measuring enzyme velocity in the laboratory -- Reversible modes of enzyme inhibition -- Enzyme inhibition as a mechanism of pharmacological intervention in disease -- Clinical value of different inhibition modalities -- Non-classical inhibition -- Enzyme assays and screening criteria -- Lead optimization -- Summary: basic information to look for.…”
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Biomarkers in drug development potential use and challenges /

Table of Contents: “…Contents: Biomarkers in drug development -- Classes of biomarkers -- Crisis in pharmaceutical development -- Potential value of biomarkers and personalized medicine to enhance probability of success -- Challenges (biology, pre-analytical, analytical) -- Possible mitigation.…”
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Series (Biomarkers)
Series (Small molecule drug discovery)

Pulmonary drug delivery

Table of Contents: “…Contents: Pulmonary drug delivery -- Therapeutic targets -- Drug categories -- Lung deposition and clearance -- Inhaled drug products -- Mechanism of droplet formation pMDIs -- In vitro tests -- In vivo considerations.…”
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Series (Drug delivery)
Series (Advances in asthma)