Search Results - "proteomics"

The chloroplast proteome

Table of Contents: “…Contents: What is proteomics and what does it measure? -- Protein identification by mass spectrometry -- The problem of complex mixtures and protein identification -- Quantitative proteomics and stable isotope labeling -- Intact protein mass measurements and top-down proteomics.…”
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Quantitative proteomics

Table of Contents: “…Contents: Proteomics -- Quantitative mass spectrometry -- Stable isotope labelling -- Label free protein quantification -- PeptideAtlas project -- Targeted mass spectrometry via multiple reaction monitoring.…”
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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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Proteomics in cardiovascular disease clinical considerations /

Table of Contents: “…Contents: Systems biology -- Definition of proteomics -- Proteomics: rationale and practical aspects -- Proteomics in cardiovascular pathophysiology -- Proteomics to detect biomarkers of cardiovascular disease -- Urinary proteomics using capillary electrophoresis / mass spectrometry -- Proteomics of coronary artery disease -- Proteomics of pre-eclampsia -- Proteomics of other cardiovascular diseases: stroke, heart failure, diabetic nephropathy.…”
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Proteomics in kidney disease clinical considerations /

Table of Contents: “…Contents: Proteomics for clinical use -- Available and applied single risk marker strategies in nephrology based on hypothesis driven biomarker search -- Open or unbiased multimarker approaches including plasma and urine proteomics -- Examples from different renal diseases -- Data from cross sectional and longitudinal studies -- Proteomics may provide insight into disease pathology -- Proteomics may provide risk stratification for clinical trials -- Example: intervention trial for type 2 diabetic subjects with high risk urinary proteomic pattern.…”
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Series (Clinical proteomics)
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Proteomic technologies and targets an overview /

Table of Contents: “…Contents: Introduction -- The relationship between genome and proteome -- Why should we analyse the proteome? -- Challenges in proteome analysis -- Dynamic range of the proteome -- Complexity of the proteome -- Spatiotemporal organisation -- Dynamic changes in protein concentrations and modifications -- Technologies for analysing the proteome -- Mass spectrometry -- Protein arrays -- Imaging -- Data analysis -- The applications of clinical proteomics -- Biomarkers -- Systems biology approaches.…”
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Clinical proteomics in neurodegenerative disease

Table of Contents: “…Contents: Neurodegenerative disease -- Dementia -- Alzheimer´s -- Clinical use of proteomic methods for diagnosis and biomarker development -- An example: CE-MS in Alzheimer research -- Scope, limits, pitfalls, prospects.…”
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Clinical proteomics in gastrointestinal cancers

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A concept for multi-marker approaches in clinical proteomics

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Clinical proteomics in the investigation of bladder cancer

Table of Contents: “…Contents: Clinical proteomics: principles of experimental design and data reporting -- Clinical needs in bladder cancer -- Bladder Cancer Biomarker discovery in urine using proteomics approaches -- How to progress towards implementation.…”
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Urinary proteomics in kidney and cardiovascular disease

Table of Contents: “…Contents: Omics technologies -- Technology platforms: (2DE-MS, LC-MS-MS, CE/MS) -- Clinical proteomics -- Precision as a function of no. of markers -- Human urinary LMW proteome database -- Requirements for biomarker selection -- How to identify valid proteomic biomarkers -- Effect size estimation and the number of samples -- Erroneous biomarkers -- Classification using different sizes of training sets -- Classification errors -- CKD biomarkers -- Biomarker validation -- Pathophysiological suggestions -- Selected urinary peptides and CKD staging -- Multicentric European PRIORITY trial -- Proteomics of coronary artery disease and of diabetic nephropathy.…”
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Series (Clinical proteomics)
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Application of proteomics in fetal and neonatal medicine

Table of Contents: “…Contents: Application of proteomics in fetal and neonatal medicine -- Principles -- Samples -- Techniques -- Statistics -- Application to obstructive nephropathy in newborns -- Application in neonatal medicine -- Conclusion.…”
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Development of glyco-biomarkers using glycoproteomics technologies

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Series (Biomarkers)
Series (Glycobiology)

Protein-glycan interactions

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Protein networks of voltage-gated Ca2+ channels proteomic & functional analysis of local Ca2+ signalling /

Table of Contents: “…Contents: Significance and molecular organization of local Ca2+ signalling -- Proteomic analysis of the nano-environment of voltage-gated Ca2+ (Cav) channels -- Structure and operation of the Cav2 channels from mammalian brain -- Operation of Cav-BK channel complexes -- Cav-BK complex as a prototypic Ca2+ nano-domain.…”
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Diagnosis of early relapse in ovarian cancer using serum proteomic profiling

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Oxidative modification of brain proteins in Alzheimer's disease and models thereof role of amyloid beta-peptide (1-42) and insights from redox proteomics /

Table of Contents: “…Contents: Alzheimer's disease and mild cognitive impairment -- Oxidative stress markers in brain, including markers for protein oxidation and lipid peroxidation -- Amyloid beta-peptide-mediated oxidative stress and Alzheimer's disease -- Redox proteomics identification of oxidatively modified brain proteins, leading to new insights into protein dysfunction in and neurotoxicity of brain cells in Alzheimer's disease and mild cognitive impairment.…”
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Protein-protein interaction networks

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Omics approaches and large-scale data analysis in ageing research 2 /

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Mapping the molecular chaperone interaction network in yeast

Table of Contents: “…Contents: Large scale proteomic screening in yeast -- The TAP-tag pulldown approach -- Understanding the principles governing protein homeostasis -- Mapping the network of the Hsp90 chaperone using physical and genetic interaction screens -- Unraveling the role of Hsp90 in pre-rRNA processing.…”
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