Search Results - "amyloid"
Suggested Topics within your search.
Suggested Topics within your search.
- Amyloid 25
- Alzheimer Disease 19
- Prions 16
- Alzheimer's disease 13
- Neurodegenerative Diseases 8
- metabolism 8
- Degeneration 7
- Nervous system 7
- pathology 7
- Protein Folding 6
- physiopathology 6
- Amyloid beta-Peptides 5
- Genetic aspects 5
- Protein Conformation 5
- Proteins 5
- drug therapy 5
- genetics 5
- Chemotherapy 4
- Treatment 4
- therapy 4
- Amyloid beta-protein 3
- Brain 3
- Dementia 3
- Diagnosis 3
- Frontotemporal Dementia 3
- Pathology 3
- Pathophysiology 3
- Protein folding 3
- Amyloidogenic Proteins 2
- Amyloidosis 2
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1
Prions and amyloids introduction /
Published 2008Table of Contents: “…Contents: Definitions of prions and amyloid -- Genetic criteria for a prion -- Prions of mammals, yeast and filamentous fungi -- Prion domains -- Non-amyloid prions.…”
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2
Imaging amyloid now that we can see it, what does it all mean? /
Published 2010Table of Contents: “…Contents: Amyloid imaging PET tracers -- Development and validation -- Amyloid imaging in dementia -- Amyloid imaging in mild cognitive impairment -- Amyloid imaging in cognitively normal elderly -- Consequences of being amyloid-positive.…”
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3
The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /
Published 2020Table of Contents: “…Contents: Functional amyloid -- Amyloid fibrils in melanosome ultrastructure and formation -- Pmel17 processing to a fibrillar form -- Evidence that Pmel17 fibrils are amyloid -- Role of multivesicular bodies in Pmel17 amyloid formation -- Multivesicular bodies in amyloid formation by other substrates.…”
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4
Amyloid fibrils as functional nanomaterials
Published 2017Table of Contents: “…Contents: Generating useful materials from proteins -- Amyloid fibrils from waste materials in a commercially scalable process -- Nanoscaffolds for enzyme immobilisation -- Templates for nanowires and biosensors.…”
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5
Amyloidosis disease caused by amyloid /
Published 2007Table of Contents: “…Contents: What is, and what is not amyloidosis -- Amyloid deposits -- Clinical amyloidosis -- Amyloid fibrillogenesis -- Tissue damage by amyloid -- Imaging amyloid in vivo -- Treatment of amyloidosis.…”
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6
The genetics and biology of the [Het-s] prion of Podospora
Published 2008Subjects: “…Amyloid. 112825…”
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7
Mechanisms of yeast prion propagation
Published 2008Table of Contents: “…Contents: Prions as infectious amyloids -- Yeast [PSI+] prion and Sup35p -- Molecular chaperone Hsp104 -- Guanidine hydrochloride as a prion propagation inhibitor -- Propagons -- Estimating propagon numbers using a stochastic model -- Generation of new propagons -- Propagation-defective mutants (PNM) -- Role of primary sequence information -- Yeast prion propagation: the unanswered questions.…”
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8
Yeast and fungal prions a help or a hindrance? /
Published 2008Subjects: “…Amyloid. 112837…”
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9
Yeast prions and protein chaperones a help or a hindrance? /
Published 2008Table of Contents: “…Contents: Role of protein chaperones in protein folding -- Yeast prions as amyloid forms of cellular proteins -- Requirement of chaperone machinery for prion propagation -- Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions.…”
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10
Molecular structure of amyloid and prion fibrils insights from solid state NMR /
Published 2008Table of Contents: “…Contents: Overview of solid state NMR methodology -- Structural model for Alzheimer's beta-amyloid fibrils -- Self-propagating polymorphism in amyloid fibrils -- Molecular basis of beta-amyloid polymorphism -- Extension of solid state NMR methods to amylin fibrils and yeast prion fibrils -- Structural basis of the generic nature of amyloid formation.…”
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11
[PIN+] prions beget prions /
Published 2008Subjects: “…Amyloid. 112849…”
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12
Propagation and variability of the yeast [PSI+] prion
Published 2008Table of Contents: “…Contents: Prion -- Yeast prions as non-chromosomal genetic determinants -- Modular structure of the Sup35 protein responsible for the yeast [PSI+] prion -- Role of the Hsp104 chaperone in [PSI+] prion propagation -- Two-level structure of the [PSI+] prion aggregates and methods for studying the size of prion polymers -- Non-prion amyloids in yeast -- Variability of the yeast [PSI+] prion.…”
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13
Similarities between prion diseases and other neurodegenerative diseases
Published 2008Subjects: “…Amyloid. 112857…”
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14
Predicting TSE transmission
Published 2008Subjects: “…Amyloid. 112861…”
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15
Generation and propagation of infectious prions by cyclic amplification of protein misfolding
Published 2008Subjects: “…Amyloid. 112865…”
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16
The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR
Published 2008Table of Contents: “…Contents: 3D structure is important -- Prion hypothesis -- Prions can form amyloids -- Amyloids -- Cross-beta arrangements give characteristic fiber diffraction patterns -- Solid-state NMR can characterize amyloid fibrils -- Atomic-resolution structure determination by NMR and x-ray -- Distance information in NMR correlation spectra -- The methodology to obtain 3D structures from solid (microcrystalline) samples has recently been developed -- Structure determination is possible -- Nevertheless, amyloids are different -- Isotopic labeling allows to disentangle the intra/inter problem -- HET-s: a functional prion -- Structural information about HET-s (218-289) from earlier measurements -- Chemical shift assignment -- To go further we need distance restraints -- Distance restraints for protein fibrils -- Intramolecular restraints -- Structure calculation -- Structural features of the fibrils -- Comparison with globular proteins.…”
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17
Transgenic mouse models of prion diseases
Published 2008Subjects: “…Amyloid. 112873…”
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18
The sequence determinants of amyloid fibril formation
Published 2007Table of Contents: “…Contents: Amyloid fibril formation is a shared property of proteins -- The effect of mutations on the aggregation of unstructured polypeptide chains -- The importance of hydrophobicity, propensity to form beta-sheet structure and charge in amyloid formation of unstructured proteins -- The regions of the sequence forming the beta-core of amyloid fibrils -- The sequence and structural determinants of aggregation for partially folded states of proteins -- Amino acid sequences have evolved to avoid formation of amyloid-like aggregates.…”
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19
Ischemic blood-brain barrier and Alzheimer's amyloid plaques development
Published 2008Table of Contents: “…Contents: Ischemic blood-brain barrier involved in Alzheimer's amyloid plaques development and full-blown Alzheimer's disease -- Brain ischemia starts Alzheimer's disease -- Association and risk factors for Alzheimer's disease -- Ischemic mechanisms in Alzheimer's disease in general.…”
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20
Adapting proteostasis to ameliorate aggregation-associated amyloid diseases
Published 2018Table of Contents: “…Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.…”
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