Search Results - "Therapeutic approach"

Pathogenic mechanisms and therapeutic approaches for the tauopathies

Table of Contents: “…Contents: Tauopathies -- Alzheimer's Disease and frontal temporal lobe dementia -- Pathogenic mechanisms -- Therapeutic approaches for the tauopathies.…”
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Series (Alzheimer's disease)
Series (Drug discovery and development in the neurosciences)

Mitochondrial inhibition as a novel therapeutic approach in drug-resistant cancer

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Ubiquitination and Alzheimer related disorders new insights and possible therapeutic approaches! /

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ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease

Table of Contents: “…Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems.…”
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Stroke rehabilitation part 2, therapies and treatments /

Table of Contents: “…Contents: Technologies -- Cognitive rehab -- Integration of new therapeutic approaches -- Shifting care to community -- Early-supported discharge.…”
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Bovine leukemia virus

Table of Contents: “…Contents: Viral replication of bovine leukemia virus -- Transmission and pathogenesis in natural and experimental hosts -- Dynamics of cell accumulation -- Novel therapeutic approach.…”
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Alzheimer's disease (AD)

Table of Contents: “…Contents: Basic epidemiological facts on AD -- Typical and atypical symptoms -- Cognitive and physical findings -- Key clinical investigations typically undertaken -- Broad therapeutic approaches -- Natural history and prognosis.…”
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SOD1-related ALS what has it told us about motor neuron degeneration? Part 2 of 2/

Table of Contents: “…Contents: Mechanisms of motor neuron injury in the presence of SOD1 mutations -- glutamate-mediated excitotoxicity -- Determinants of fast and slow disease progression -- Therapeutic approaches including gene therapy.…”
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Astrocytes and Alexander disease the first - but not last - primary astrocyte disease /

Table of Contents: “…Contents: GFAP in astrocytes: isolation, genetics and function -- Alexander disease: clinical and pathologic features -- Mouse models for studying pathogenesis -- Potential therapeutic approaches: reduction of GFAP and manipulation of stress response.…”
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Steroid hormones and their receptors in breast cancer

Table of Contents: “…Contents: Development and types of breast cancers -- Molecular and cellular aspects of hormone action on breast cells -- Natural and synthetic estrogens -- Basis for endocrine therapies -- Alternative/emerging therapeutic approaches -- Strategies for breast cancer prevention.…”
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Current directions in the prevention and treatment of Alzheimer's disease

Table of Contents: “…Contents: Amyloid build-up and the importance of early diagnosis -- The potential of inhibiting vs. clearing amyloid aggregation -- Different potential therapeutic approaches designed for different stages of Alzheimer's -- The future of therapies targeting amyloid deposition.…”
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Antiphospholipid syndrome and Lupus

Table of Contents: “…Contents: Genetics vs. environmental triggers in antiphospholipid syndrome and Lupus -- Current challenges in diagnosis and the limitation of available treatments -- Open questions with regard to the underlying mechanisms of antiphospholipid syndrome and Lupus -- Potential directions in the development of diagnostic tools and therapeutic approaches.…”
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KV10.1 potassium channels in cancer

Table of Contents: “…Structure and expression profile -- Aberrant expression of KV10.1 in cancer cells -- Prognostic values of KV10.1 expression -- Therapeutic approaches using KV10.1 as target -- Functional antibodies against KV10.1 and their potential in oncology.…”
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Sjogren's syndrome current knowledge and future prospects /

Table of Contents: “…Contents: Introduction to Sjögren's syndrome -- Humoral and cellular autoimmune responses in Sjögren's syndrome -- Description of heterogenic clinical features of disease -- Pathogenetic/immunopathologic aspects and associations with clinical phenotypes -- The need for precise therapeutic approaches -- Development and features of lymphoma in Sjögren's syndrome -- Risk factors for development of severe disease -- Biomarkers for disease severity, outcome and lymphoma.…”
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Palin parent-child interaction therapy

Table of Contents: “…Contents: Multifactorial model of onset & development of stuttering -- Therapeutic approach: core values -- Risk factors for young children who stutter -- Screening for vulnerability to persistence and appropriate care pathways -- Assessment of stuttering -- Principles of Palin Parent-Child Interaction (PCI) Therapy -- Using video analysis in PCI therapy -- Three main strands of PCI therapy: interaction, family, child (strategies).…”
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The neurological symptoms of COVID-19

Table of Contents: “…Contents: Diversity and incidence of neurological symptoms attributable to COVID-19 -- Mechanisms by which SARS-CoV-2 infection triggers neurological symptoms -- Singularity of SARS-CoV-2, among coronaviruses, in triggering neurological symptoms -- Therapeutic approaches to prevent or improve neurological symptoms -- Incidence of psychiatric symptoms resulting from COVID-19 in a subset of patients -- Relationship between neurological and psychiatric symptoms.…”
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Hepatic encephalopathy in cirrhosis a disorder of glial-neuronal signalling /

Table of Contents: “…Contents: Classification of hepatic encephalopathy -- Hepatic encephalopathy in cirrhosis -- Transjugular intrahepatic portosystemic shunt (TIPS) -- Hepatic encephalopathy post-TIPS -- Neuropathology of hepatic encephalopathy in chronic liver failure -- Cirrhosis-related Parkinsonism -- PET studies in cirrhosis -- Neuroinflammation and hepatic encephalopathy in cirrhosis -- Systemic inflammatory response syndrome (SIRS) in cirrhosis -- Translocator protein and hepatic encephalopathy in cirrhosis -- Modulatory site for neurosteroids -- Prevention and treatment of hepatic encephalopathy in cirrhosis -- Emerging new therapeutic approaches.…”
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Mechanism-based therapies for heart failure and cardiac arrhythmias

Table of Contents: “…Contents: Introduction to excitation-contraction coupling -- History of the field of EC coupling -- Introduction to the ryanodine receptor/calcium release channel (RyR2) -- Mechanisms that regulate the RyR2 channel during stress -- Defective regulation of RyR2 in heart failure -- Evidence that diastolic sarcoplasmic reticulum (SR) calcium leak causes heart failure and arrhythmias in vivo -- Novel therapeutic approaches to treating heart failure and preventing sudden cardiac death by fixing the leak in RyR2 channels.…”
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Series (Calcium signaling 1)
Series (Calcium signaling 2)

Lysosomal storage diseases

Table of Contents: “…Contents: Lysosomes are multifunctional -- Lysosome related organelles -- Complexity & functions of lysosomal proteins -- Lysosomal storage diseases -- Sphingolipid lysosomal storage diseases as an example -- Lysosomal diseases: multimorbidity disorders -- Pathogenic cascade beyond the Lysosomal System -- Specific therapies approved for some diseases -- Molecular mechanisms and therapeutic approaches of LSDs -- Lysosomal enzymes -- ERTs: approved or in advanced clinical trials -- Approved small molecules: SRT & EET -- Multiple gene therapy trials: enzyme deficiencies -- Cellular organelles targeted by LSD therapies -- Lysosomal & neurodegenerative diseases.…”
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Therapeutic delivery of RNAi

Table of Contents: “…Contents: RNAi therapeutics development -- RNAi cellular activity -- In vivo siRNA delivery is key -- Clinically viable siRNA deliveries -- Local delivery of siRNA -- Gene silencing in tumors -- Cancer target validation in vivo -- RNAi effects in mouse brain, joints, eyes and lungs -- siRNA therapeutics in primate models -- Challenges to siRNA systemic delivery -- Systemic delivery technology -- Targeted nanoparticle siRNA delivery -- Self assembled nanoparticle -- Integrin av-beta is a validated target -- Dual-targeted therapeutic approach -- Neovasculature targeting siRNA -- Multi-targeted anti-angiogenesis -- Efficient targeted systemic delivery -- Systemic siRNA delivery to eyes -- Systemic siRNA delivery for neuroblastoma treatment -- Tumor neovasculature inhibition -- siRNA/Atelocollagen anti-tumor efficacy -- Transferrin-mediated systemic delivery -- Antibody-mediated tumor targeting -- Targeted anti-HBV activity -- RNAi effect of chol-siRNA -- PEI-mediated siRNA lung targeting -- Clinicallyviable delivery is the key for successful siRNA therapeutics.…”
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