Search Results - "amyloid"
Suggested Topics within your search.
Suggested Topics within your search.
- Amyloid 49
- Alzheimer Disease 34
- Prions 32
- Alzheimer's disease 26
- metabolism 13
- Neurodegenerative Diseases 12
- Protein Folding 12
- physiopathology 12
- Proteins 11
- pathology 11
- Nervous system 10
- Protein Conformation 10
- drug therapy 10
- Chemotherapy 9
- Degeneration 9
- Genetic aspects 9
- genetics 9
- Amyloid beta-Peptides 8
- Treatment 8
- therapy 7
- Amyloid beta-protein 6
- Pathophysiology 6
- Protein folding 6
- Brain 5
- Dementia 5
- Diagnosis 5
- Pathology 5
- Amyloidosis 4
- Diagnostic Imaging 4
- Frontotemporal Dementia 4
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1
Imaging amyloid now that we can see it, what does it all mean? /
Published 2010Table of Contents: “…Contents: Amyloid imaging PET tracers -- Development and validation -- Amyloid imaging in dementia -- Amyloid imaging in mild cognitive impairment -- Amyloid imaging in cognitively normal elderly -- Consequences of being amyloid-positive.…”
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2
Prions and amyloids introduction /
Published 2008Table of Contents: “…Contents: Definitions of prions and amyloid -- Genetic criteria for a prion -- Prions of mammals, yeast and filamentous fungi -- Prion domains -- Non-amyloid prions.…”
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3
Imaging amyloid now that we can see it, what does it all mean? /
Published 2010Table of Contents: “…Contents: Amyloid imaging PET tracers -- Development and validation -- Amyloid imaging in dementia -- Amyloid imaging in mild cognitive impairment -- Amyloid imaging in cognitively normal elderly -- Consequences of being amyloid-positive.…”
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4
Prions and amyloids introduction /
Published 2008Table of Contents: “…Contents: Definitions of prions and amyloid -- Genetic criteria for a prion -- Prions of mammals, yeast and filamentous fungi -- Prion domains -- Non-amyloid prions.…”
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5
The dark side of amyloid Pmel17, a natural amyloid in melanosome biogenesis /
Published 2008Table of Contents: “…Contents: Functional amyloid -- Amyloid fibrils in melanosome ultrastructure and formation -- Pmel17 processing to a fibrillar form -- Evidence that Pmel17 fibrils are amyloid -- Role of multivesicular bodies in Pmel17 amyloid formation -- Multivesicular bodies in amyloid formation by other substrates.…”
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6
The dark side of amyloid PMEL, a natural amyloid in melanosome biogenesis /
Published 2020Table of Contents: “…Contents: Functional amyloid -- Amyloid fibrils in melanosome ultrastructure and formation -- Pmel17 processing to a fibrillar form -- Evidence that Pmel17 fibrils are amyloid -- Role of multivesicular bodies in Pmel17 amyloid formation -- Multivesicular bodies in amyloid formation by other substrates.…”
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7
Amyloid fibrils and prefibrillar aggregates molecular and biological properties /
Published 2013Subjects: “…Amyloid.…”
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8
Mechanism of prion generation in vitro
Published 2008Subjects: “…Amyloid.…”
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9
The genetics and biology of the [Het-s] prion of Podospora
Published 2008Subjects: “…Amyloid.…”
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10
Mechanisms of yeast prion propagation
Published 2008Table of Contents: “…Contents: Prions as infectious amyloids -- Yeast [PSI+] prion and Sup35p -- Molecular chaperone Hsp104 -- Guanidine hydrochloride as a prion propagation inhibitor -- Propagons -- Estimating propagon numbers using a stochastic model -- Generation of new propagons -- Propagation-defective mutants (PNM) -- Role of primary sequence information -- Yeast prion propagation: the unanswered questions.…”
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11
Chaperones and prions
Published 2008Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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12
Yeast and fungal prions a help or a hindrance? /
Published 2008Subjects: “…Amyloid.…”
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13
Yeast prions and protein chaperones a help or a hindrance? /
Published 2008Table of Contents: “…Contents: Role of protein chaperones in protein folding -- Yeast prions as amyloid forms of cellular proteins -- Requirement of chaperone machinery for prion propagation -- Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions.…”
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14
Molecular structure of amyloid and prion fibrils insights from solid state NMR /
Published 2008Table of Contents: “…Contents: Overview of solid state NMR methodology -- Structural model for Alzheimer's beta-amyloid fibrils -- Self-propagating polymorphism in amyloid fibrils -- Molecular basis of beta-amyloid polymorphism -- Extension of solid state NMR methods to amylin fibrils and yeast prion fibrils -- Structural basis of the generic nature of amyloid formation.…”
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15
[PIN+] prions beget prions /
Published 2008Subjects: “…Amyloid.…”
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16
Propagation and variability of the yeast [PSI+] prion
Published 2008Table of Contents: “…Contents: Prion -- Yeast prions as non-chromosomal genetic determinants -- Modular structure of the Sup35 protein responsible for the yeast [PSI+] prion -- Role of the Hsp104 chaperone in [PSI+] prion propagation -- Two-level structure of the [PSI+] prion aggregates and methods for studying the size of prion polymers -- Non-prion amyloids in yeast -- Variability of the yeast [PSI+] prion.…”
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17
Similarities between prion diseases and other neurodegenerative diseases
Published 2008Subjects: “…Amyloid.…”
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18
Predicting TSE transmission
Published 2008Subjects: “…Amyloid.…”
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19
Generation and propagation of infectious prions by cyclic amplification of protein misfolding
Published 2008Subjects: “…Amyloid.…”
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20
The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR
Published 2008Table of Contents: “…Contents: 3D structure is important -- Prion hypothesis -- Prions can form amyloids -- Amyloids -- Cross-beta arrangements give characteristic fiber diffraction patterns -- Solid-state NMR can characterize amyloid fibrils -- Atomic-resolution structure determination by NMR and x-ray -- Distance information in NMR correlation spectra -- The methodology to obtain 3D structures from solid (microcrystalline) samples has recently been developed -- Structure determination is possible -- Nevertheless, amyloids are different -- Isotopic labeling allows to disentangle the intra/inter problem -- HET-s: a functional prion -- Structural information about HET-s (218-289) from earlier measurements -- Chemical shift assignment -- To go further we need distance restraints -- Distance restraints for protein fibrils -- Intramolecular restraints -- Structure calculation -- Structural features of the fibrils -- Comparison with globular proteins.…”
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