Search Results - "Evolution"

Pleiotropy cellular-molecular evolution in action /

Table of Contents: “…Contents: Pleiotropy as a Rubik's Cube ("Repurposing" of genes in response to evolution) -- Complex physiologic phenotypes as homologs of the unicellular cell membrane -- Driving factors for "repurposing" of genes -- Examples of pleiotropic "repurposing" of genes -- Aging vs. …”
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How to "deconvolute" lung evolution part 1 [of 3]. Vertebrate ontogeny : the "short history" of evolution /

Table of Contents: “…Contents: Ontogeny, the "short history" of the organism -- Embryogenesis, blastula to gastrula -- Molecular signaling and morphogenesis -- Alternating extrinsic/intrinsic selection pressure -- Swim Bladder-Lung homology -- Continuum from ontogeny to phylogeny, homeostasis, repair -- PTHrP necessary for alveolarization -- PTHrP, Glucocorticoid and ßAdrenergic Receptor gene duplications -- Evolution of Endothermy.…”
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How to "deconvolute" lung evolution part 3, Evolutionary lessons from cell culture /

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How to "deconvolute" lung evolution part 2 [of 3]. The evolutionary origins of pulmonary physiology /

Table of Contents: “…Contents: Cortisol, lung surfactant and lung development -- Continuum from phylogeny and ontogeny to homeostasis and repair -- Functional genomic homology between SB and lung -- PTHrP and normal lung development -- PTHrP and gravity -- The origins of life: cellular evolution -- Oxygen/stretch and positive selection pressure -- Lung PTHrP/R as "blue print" for other terrestrial exaptations.…”
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The dynamic interactions between cellular-molecular physiology and the environment part 2, The unicellular state as the level of selection - epigenetics /

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The dynamic interactions between cellular-molecular physiology and the environment part 1, The cellular-molecular approach to evolution as niche construction /

Subjects: “…Cells Evolution. 98351…”
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On the utility of a mechanistic approach to physiology part 1: Descriptive vs. mechanistic biology /

Table of Contents: “…Reductionism: philosophical views about nature -- Molecular changes mediating evolution -- Cell communication as mechanism of novelty -- From phylogeny-ontogeny to homeostasis & repair -- Homeostasis as the mechanism for evolution -- Explicate/Implicate order.…”
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Evolutionary biology, cell-cell communication, and complex disease by Torday, John S.

Subjects: An electronic book accessible through the World Wide Web; click to view

On the utility of a mechanistic approach to physiology part 2, the evolutionary origin of endothermy /

Table of Contents: “…Contents: Evolution of endothermy -- PTHrP, Glucocorticoid and β-Adrenergic Receptor gene duplications -- Hypoxia integrates respiratory and endocrine systems -- Selection pressure for integrated physiology: lung, kidney, heart -- Ontogeny-phylogeny of lung cell evolution -- Swim bladder-lung functional homology -- PTHrP is stretch-regulated -- Chemiosmosis-homeostasis and the origins of life -- Vertical integration of the effect of cholesterol on homeostasis -- Cell-cell interactions and adaptation to oxygen -- Endothermy as exaptation of oxygen adaptation -- Physiologic homology based on cell-cell interactions.…”
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Using lung evolution as a cipher for physiology - pathophysiology

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The unicellular origins of complex physiology

Table of Contents: “…Contents: Cholesterol's critical role in the evolution of eukaryotes -- Vertical integration of calcium/lipid epistasis throughout vertebrate physiology -- The unicellular perspective: aspects of physiology simplified -- Simplification of physiology: homologies unseen by descriptive physiology -- Physiology as fractal expressions of the unicellular state -- The fractal principle: functional integration of physiology from first principles.…”
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The evolutionary web of life

Table of Contents: “…Contents: Rationale for homeostatic change as evolution -- Historic perspective on homeostasis -- Lung surfactant as a molecular fossil -- Evolution (ontogeny + phylogeny + homeostasis) -- Molecular evolutionary fossils -- Homology of skin and lung cell physiology -- Lung-skin-brain homology -- Trojan horse effect and asthma -- Homology of alveolus and glomerulus -- Fluid distension and mechanotransduction -- Evolutionary permutations and combinations -- Aging as the inverse of development -- Foregut plasticity -- Evolutionary biology inconsistencies & paradoxes -- The unicellular bauplan -- Pleiotropy and evolution -- From unicellular to multicellular organisms -- Evolution of whole animal physiology -- Alveolar homeostasis -- Phylogenetic parallelisms.…”
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Lung biology and lung disease

Table of Contents: “…Contents: The evolution of the vertebrate lung -- Vertebrate evolution from unicellular organisms is reflected in lung development -- Stretch-regulated pathways of lung development leading to homeostasis can fail, leading to chronic lung disease -- The cell/molecular pathways that integrate lung development and homeostasis can serve to effectively diagnose and treat chronic lung disease.…”
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The dynamic interactions between cellular-molecular physiology and the environment future directions in cellular-molecular evolutionary biology /

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The dynamic interactions between cellular-molecular physiology and the environment part 3, Case studies in pathophysiology : how to exploit cellular-molecular evolution /

Table of Contents: “…Contents: Simplification of structure and function as reverse evolution -- Chronic diseases & pathologies in different tissues and organs -- Breakdown in cell-cell communication -- Fibrosis & PPARɣ agonists -- Sensing loss of homeostasis & cellular perturbations.…”
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