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Modifications of pyruvate handling in health and disease

Table of Contents: “…Contents: Potential metabolic fates of pyruvate -- Lactate transport -- Role of pyruvate dehydrogenase complex (PDC) -- Regulation of PDC -- Mechanisms of activation of PDC by pyruvate dehydrogenase phosphatases -- Pyruvate dehydrogenase kinase (PDK) expression and regulation -- Multi-site phosphorylation -- Transcription factors regulating PDK4 expression -- Anaplerosis and cataplerosis -- Pyruvate carboxylase -- Insulin secretion and action -- Glucose/fatty-acid cycle -- Consequences of PDK4 upregulation -- Disorders of pyruvate handling.…”
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Modifications of pyruvate handling in health and disease

Table of Contents: “…Contents: Potential metabolic fates of pyruvate -- Lactate transport -- Role of pyruvate dehydrogenase complex (PDC) -- Regulation of PDC -- Mechanisms of activation of PDC by pyruvate dehydrogenase phosphatases -- Pyruvate dehydrogenase kinase (PDK) expression and regulation -- Multi-site phosphorylation -- Transcription factors regulating PDK4 expression -- Anaplerosis and cataplerosis -- Pyruvate carboxylase -- Insulin secretion and action -- Glucose/fatty-acid cycle -- Consequences of PDK4 upregulation -- Disorders of pyruvate handling.…”
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Modifications of pyruvate handling in health and disease

Table of Contents: “…Contents: Potential metabolic fates of pyruvate -- Lactate transport -- Role of pyruvate dehydrogenase complex (PDC) -- Regulation of PDC -- Mechanisms of activation of PDC by pyruvate dehydrogenase phosphatases -- Pyruvate dehydrogenase kinase (PDK) expression and regulation -- Multi-site phosphorylation -- Transcription factors regulating PDK4 expression -- Anaplerosis and cataplerosis -- Pyruvate carboxylase -- Insulin secretion and action -- Glucose/fatty-acid cycle -- Consequences of PDK4 upregulation -- Disorders of pyruvate handling.…”
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