Search Results - "prion"

Generation and propagation of infectious prions by cyclic amplification of protein misfolding

Table of Contents: “…Contents: Prions as infectious proteins and the mechanism of replication -- The rationale and proof of concept for the PMCA technology -- Multiple applications of PMCA -- Generation of infectious prions by PMCA -- Studies of prion strains and species barrier -- Use of PMCA for prion detection and diagnosis.…”
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Endoplasmic reticulum stress in neurodegenerative diseases

Table of Contents: “…Contents: Neurodegenerative disease -- Misfolded aggregates deposited in the brain -- Research strategy -- Prion diseases -- Two conformations of the prion protein -- Experimental scrapie model in mice -- Upregulation of ER chaperones -- ER-stress and UPR in human CJD -- PrP interaction with ER chaperones in brain -- PrPSc induction of ER-stress and neuronal death -- Calcineurin properties -- A novel treatment for prion diseases.…”
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