Search Results - "oxidative stress"

Oxidative stress in ALS

Table of Contents: “…Contents: Key facts -- The normal human motor system -- Motor neurone disease: clinical consequences -- Spared motor neurone groups -- Prognosis -- Features of motor neurones which may underlie selective vulnerability -- Complex and multifactorial disease -- Genetic factors -- SOD1 mutations -- Potential mechanisms of neuronal oxidative stress -- Sources of intracellular oxidative stress -- Mitochondrial free radical production -- ROS -- Evidence for the role of oxidative stress in ALS -- NSC34 cell model -- G93A mutant SOD1 -- Oxidative stress in human ALS -- Major pathogenetic factors -- Glutamate -- Excitotoxicity -- Mitochondrial dysfunction -- Potential mechanisms of action of antioxidant drugs -- Clinical trials.…”
Get full text
Series

Oxidative stress in ALS

Table of Contents: “…Contents: Key facts -- The normal human motor system -- Motor neurone disease: clinical consequences -- Spared motor neurone groups -- Prognosis -- Features of motor neurones which may underlie selective vulnerability -- Complex and multifactorial disease -- Genetic factors -- SOD1 mutations -- Potential mechanisms of neuronal oxidative stress -- Sources of intracellular oxidative stress -- Mitochondrial free radical production -- ROS -- Evidence for the role of oxidative stress in ALS -- NSC34 cell model -- G93A mutant SOD1 -- Oxidative stress in human ALS -- Major pathogenetic factors -- Glutamate -- Excitotoxicity -- Mitochondrial dysfunction -- Potential mechanisms of action of antioxidant drugs -- Clinical trials.…”
Get full text
Series

Oxidative stress in ALS

Table of Contents: “…Contents: Key facts -- The normal human motor system -- Motor neurone disease: clinical consequences -- Spared motor neurone groups -- Prognosis -- Features of motor neurones which may underlie selective vulnerability -- Complex and multifactorial disease -- Genetic factors -- SOD1 mutations -- Potential mechanisms of neuronal oxidative stress -- Sources of intracellular oxidative stress -- Mitochondrial free radical production -- ROS -- Evidence for the role of oxidative stress in ALS -- NSC34 cell model -- G93A mutant SOD1 -- Oxidative stress in human ALS -- Major pathogenetic factors -- Glutamate -- Excitotoxicity -- Mitochondrial dysfunction -- Potential mechanisms of action of antioxidant drugs -- Clinical trials.…”
Get full text
Series

Oxidative stress in amyotrophic lateral sclerosis (ALS) part 1 of 2 /

Table of Contents: “…Contents: Introduction to Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease (MND) -- Clinical genetic and pathological heterogeneity of MND -- Mechanisms of neuronal oxidative stress -- Mitochondria oxidative stress response -- Antioxidant defence mechanisms -- Evidence for the role of oxidative stress in SOD1 MND -- The role of Nrf2 in MND.…”
Get full text
Series

Oxidative stress in amyotrophic lateral sclerosis (ALS) part 2 of 2 /

Table of Contents: “…Contents: Evidence for oxidative stress in other subtypes of Motor Neuron Disease (MND) -- Causes of oxidative stress in MND -- The role of TDP-43 in MND -- Eleven main pathophysiological mechanisms in ALS/MND -- Oxidative stress as a therapeutic target in MND -- Ebselen -- Riluzole -- Edaravone, copper ATSM, and Dimethyl fumarate trials.…”
Get full text
Series

Oxidative stress in amyotrophic lateral sclerosis (ALS) part 1 of 2 /

Table of Contents: “…Contents: Introduction to Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease (MND) -- Clinical genetic and pathological heterogeneity of MND -- Mechanisms of neuronal oxidative stress -- Mitochondria oxidative stress response -- Antioxidant defence mechanisms -- Evidence for the role of oxidative stress in SOD1 MND -- The role of Nrf2 in MND.…”
Get full text
Series

Oxidative stress in amyotrophic lateral sclerosis (ALS) part 2 of 2 /

Table of Contents: “…Contents: Evidence for oxidative stress in other subtypes of Motor Neuron Disease (MND) -- Causes of oxidative stress in MND -- The role of TDP-43 in MND -- Eleven main pathophysiological mechanisms in ALS/MND -- Oxidative stress as a therapeutic target in MND -- Ebselen -- Riluzole -- Edaravone, copper ATSM, and Dimethyl fumarate trials.…”
Get full text
Series