Search Results - "Genetics"

SOD1-related ALS what has it told us about motor neuron degeneration? Part 2 of 2/

Subjects: “…Amyotrophic Lateral Sclerosis genetics. 83293…”
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SOD1-related ALS what has it told us about motor neuron degeneration? Part 1 of 2 /

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Oxidative stress in amyotrophic lateral sclerosis (ALS) part 1 of 2 /

Table of Contents: “…Contents: Introduction to Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease (MND) -- Clinical genetic and pathological heterogeneity of MND -- Mechanisms of neuronal oxidative stress -- Mitochondria oxidative stress response -- Antioxidant defence mechanisms -- Evidence for the role of oxidative stress in SOD1 MND -- The role of Nrf2 in MND.…”
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Oxidative stress in amyotrophic lateral sclerosis (ALS) part 2 of 2 /

Subjects: “…Amyotrophic Lateral Sclerosis genetics. 82501…”
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Oxidative stress in ALS

Table of Contents: “…Contents: Key facts -- The normal human motor system -- Motor neurone disease: clinical consequences -- Spared motor neurone groups -- Prognosis -- Features of motor neurones which may underlie selective vulnerability -- Complex and multifactorial disease -- Genetic factors -- SOD1 mutations -- Potential mechanisms of neuronal oxidative stress -- Sources of intracellular oxidative stress -- Mitochondrial free radical production -- ROS -- Evidence for the role of oxidative stress in ALS -- NSC34 cell model -- G93A mutant SOD1 -- Oxidative stress in human ALS -- Major pathogenetic factors -- Glutamate -- Excitotoxicity -- Mitochondrial dysfunction -- Potential mechanisms of action of antioxidant drugs -- Clinical trials.…”
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