Search Results - "DNA"

Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease

Table of Contents: “…Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies.…”
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Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Spectrum of mitochondrial diseases -- Mitochondrial metabolic pathway -- MtDNA mutations and disease -- Pathological features -- MELAS -- Genetic epidemiology of mtDNA mutations -- Structural components of respiratory chain complexes -- Mitochondrial DNA metabolism -- Mitochondrial proteins and oxidative phosphorylation -- Fatal mtDNA depletion syndrome -- POLG mutations -- Environmental influences on PD causation -- PARK genes -- Huntington's disease and mtDNA mutations -- Genetic basis of Friedreich's ataxia -- Mitochondrial toxins.…”
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Series (Mitochondrial biogenesis)
Series (Neurodegenerative diseases)