Search Results - "nanoparticle"

Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1

Table of Contents: “…-- Major goals of anti-HIV therapies -- Combinatorial RNA based therapy for HIV -- Applying RNAi for the treatment of human diseases -- treat HIV infection by systemic delivery of small RNAs -- Aptamers -- Chimeric-siRNA aptamer uptake into gp120 expressing cells -- Aptamer-targeted RNA interference for HIV-1 therapy -- Aptamer and aptamer chimera mediated inhibition of HIV-1 -- Small animal model for studying anti-HIV RNAi based therapies -- Both aptamer and aptamer chimera inhibit HIV infection -Aptamer and chimeric aptamer-siRNA prevent CD4+ cell decline -- Aptamer and dsiRNAS effect on viral load -- Flexible PAMAM dendrimers with a triethanolamine core -- Dendrimers plus siRNAs form nanoparticles, protect siRNA from degradation and deliver siRNAs to T-lymphocytes -- G5 dendrimer delivered siRNAs down regulate target mRNAs in vitro -- Multiplex siRNAs for HIV-1 treatment -- In vivo analyses of G5 dendrimer delivered siRNAs -- Reductions in HIV loads following dendrimer siRNA injections -- Dendrimer-siRNA complexes protect HIV infected RAG-hu mice from CD4 T cell loss -- Bio distribution of G5 dendrimer siRNAs.…”
Get full text
Series

Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1

Table of Contents: “…-- Major goals of anti-HIV therapies -- Combinatorial RNA based therapy for HIV -- Applying RNAi for the treatment of human diseases -- treat HIV infection by systemic delivery of small RNAs -- Aptamers -- Chimeric-siRNA aptamer uptake into gp120 expressing cells -- Aptamer-targeted RNA interference for HIV-1 therapy -- Aptamer and aptamer chimera mediated inhibition of HIV-1 -- Small animal model for studying anti-HIV RNAi based therapies -- Both aptamer and aptamer chimera inhibit HIV infection -Aptamer and chimeric aptamer-siRNA prevent CD4+ cell decline -- Aptamer and dsiRNAS effect on viral load -- Flexible PAMAM dendrimers with a triethanolamine core -- Dendrimers plus siRNAs form nanoparticles, protect siRNA from degradation and deliver siRNAs to T-lymphocytes -- G5 dendrimer delivered siRNAs down regulate target mRNAs in vitro -- Multiplex siRNAs for HIV-1 treatment -- In vivo analyses of G5 dendrimer delivered siRNAs -- Reductions in HIV loads following dendrimer siRNA injections -- Dendrimer-siRNA complexes protect HIV infected RAG-hu mice from CD4 T cell loss -- Bio distribution of G5 dendrimer siRNAs.…”
Get full text
Series

Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1

Table of Contents: “…-- Major goals of anti-HIV therapies -- Combinatorial RNA based therapy for HIV -- Applying RNAi for the treatment of human diseases -- treat HIV infection by systemic delivery of small RNAs -- Aptamers -- Chimeric-siRNA aptamer uptake into gp120 expressing cells -- Aptamer-targeted RNA interference for HIV-1 therapy -- Aptamer and aptamer chimera mediated inhibition of HIV-1 -- Small animal model for studying anti-HIV RNAi based therapies -- Both aptamer and aptamer chimera inhibit HIV infection -Aptamer and chimeric aptamer-siRNA prevent CD4+ cell decline -- Aptamer and dsiRNAS effect on viral load -- Flexible PAMAM dendrimers with a triethanolamine core -- Dendrimers plus siRNAs form nanoparticles, protect siRNA from degradation and deliver siRNAs to T-lymphocytes -- G5 dendrimer delivered siRNAs down regulate target mRNAs in vitro -- Multiplex siRNAs for HIV-1 treatment -- In vivo analyses of G5 dendrimer delivered siRNAs -- Reductions in HIV loads following dendrimer siRNA injections -- Dendrimer-siRNA complexes protect HIV infected RAG-hu mice from CD4 T cell loss -- Bio distribution of G5 dendrimer siRNAs.…”
Get full text
Series