Search Results - "recombinant DNA"

The generation of diversity in antibody genes

Table of Contents: “…Contents: Historical perspective on antibodies and immunity -- Nature and structure of antibodies and immunoglobulin fold -- Theories of antibody formation -- Clonal selection theory -- Mechanisms contributing to antibody diversity -- Organization of immunoglobulin loci -- Immunoglobulin gene rearrangement and generation of the primary repertoire -- RSS elements -- RAG genes and mechanism of V-D-J joining -- Membrane immunoglobulin and the B-cell antigen receptor -- Secondary antibody repertoire and diversification of rearranged immunoglobulin genes -- Affinity maturation -- Somatic hypermutation, gene conversion and class-switch recombination -- DNA deamination as a central trigger for these three diversification processes -- Detailed pathways of antibody gene diversification -- AID and the evolution of DNA deamination.…”
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