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Small interfering RNA induced transcriptional gene silencing in human cells

Table of Contents: “…Contents: How siRNAs mediate transcriptional gene silencing (TGS) in human cells -- Histone methylation -- Dependency on active RNA polymerase II mediated transcription -- siRNA-mediated TGS -- H3K9 and H3K27 methylation of the targeted EF1A promoter -- Nuclear specific delivery of the siRNA -- Antisense strand-specific siRNA-mediated TGS of EF1A -- Targeting of the U3 region of the HIV-1 LTR/promoter -- Antisense strand of siRNA EF2 interacts with FLAG-tagged DNMT3A and the tri-methylated H3K27 methyl mark -- siRNA mediated targeting of genomic regions -- RNA Pol-II function -- Transcriptional gene silencing in human cells.…”
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