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Nuclear receptors transcriptional functions /

Table of Contents: “…Contents: Introduction to transcription factors -- Nuclear receptors as ligand-dependent transcription factors -- Classes of nuclear receptor -- Nuclear receptor ligands: agonists and antagonists -- Nuclear receptor phylogeny -- Nuclear receptor isoforms -- The nuclear receptor DNA-binding domain -- Hormone response elements -- The nuclear receptor ligand-binding domain -- Nuclear receptor mechanism -- Subcellular localization of nuclear receptors -- The effect of ligand binding -- Nuclear receptor coregulators -- Initial discoveries of coregulators -- The SRC/p160 coregulator family -- Nuclear receptor-coregulator interaction motifs -- Histone acetylation and chromatin structure -- The Nuclear Receptor Signaling Atlas (NURSA) -- Chromatin immunoprecipitation as a tool in nuclear receptor mechanism -- Functional differences between type I and type II nuclear receptors -- The coregulator exchange -- DNA-binding independent functions -- Transrepression -- The role of kinases.…”
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