Search Results - "prion"

Similarities between prion diseases and other neurodegenerative diseases

Table of Contents: “…Contents: Pathology of diseases -- Prion diseases -- The first family with a prion mutation: Creutzfeldt-Jacob disease -- Alzheimer's disease -- 7Mb duplication of locus around APP -- APP probably a locus for "sporadic" Alzheimer's disease -- Diseases with only Lewy bodies: Parkinson's disease and Lewy body dementia -- Iowa kindred structure -- alpha-synuclein -- Diseases with only Tau pathology -- The microtubule associated protein tau -- Evolution of human tau haplotypes -- Tagging SNPs selection -- More complex than just H1/H2 -- Association with PSP is driven by H1c allele -- Primary tauopathies -- "Prion-like " behaviour of A-beta -- Does the "spreading" of diseases reflect a less extreme version of infection? …”
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Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /

Table of Contents: “…Contents: Protein pathology of disease -- Loci underlying autosomal dominant neurodegenerative disease -- Prion mutations causing Gerstmann Straussler syndrome and hereditary Creuzfeldt-Jakob disease -- Tau mutations cause autosomal dominant frontal temporal dementia -- Alpha-synuclein mutations cause autosomal dominant Parkinson's disease -- How genetic variability of these genes contributes to the risk of sporadic disease.…”
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