Search Results - "proteins"

Intrinsically unstructured proteins regulation and disease /

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
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Intrinsically unstructured proteins regulation and disease /

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
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Intrinsically unstructured proteins regulation and disease /

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
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Structure, evolution and dynamics of transcriptional regulatory networks

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Transcriptional networks -- Network motifs -- Scale-free networks -- How transcriptional networks evolve -- Mechanisms for the creation of new genes -- Gene duplication and network growth -- Evolution of local network structure -- Gene regulatory network and expression data -- Back-tracking method to find active sub-networks -Temporal dynamics of local & global structure -- Topological properties -- Dynamic properties -- Hierarchical organisation in networks & of regulatory proteins -- Noise in protein levels -- Non-genetic variation -- Phenotypic variability in fluctuating environments -- Differential cell-fate outcome -- Node dynamics.…”
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Structure, evolution and dynamics of transcriptional regulatory networks

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Transcriptional networks -- Network motifs -- Scale-free networks -- How transcriptional networks evolve -- Mechanisms for the creation of new genes -- Gene duplication and network growth -- Evolution of local network structure -- Gene regulatory network and expression data -- Back-tracking method to find active sub-networks -Temporal dynamics of local & global structure -- Topological properties -- Dynamic properties -- Hierarchical organisation in networks & of regulatory proteins -- Noise in protein levels -- Non-genetic variation -- Phenotypic variability in fluctuating environments -- Differential cell-fate outcome -- Node dynamics.…”
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Structure, evolution and dynamics of transcriptional regulatory networks

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Transcriptional networks -- Network motifs -- Scale-free networks -- How transcriptional networks evolve -- Mechanisms for the creation of new genes -- Gene duplication and network growth -- Evolution of local network structure -- Gene regulatory network and expression data -- Back-tracking method to find active sub-networks -Temporal dynamics of local & global structure -- Topological properties -- Dynamic properties -- Hierarchical organisation in networks & of regulatory proteins -- Noise in protein levels -- Non-genetic variation -- Phenotypic variability in fluctuating environments -- Differential cell-fate outcome -- Node dynamics.…”
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