Search Results - "proteins"

LKB1 pathway and its role in cancer

Table of Contents: “…Contents: Mutations in LKB1 kinase cause Peutz Jeghers cancer syndrome -- LKB1-activation and effects -- LKB1/AMPK signaling pathway inhibits mTOR -- Evaluating the role of LKB1 in regulating PTEN-induced tumourigenesis -- AMPK-activators-mechanisms of action -- AMPK-activators delay tumor onset in mice -- Metformin as a useful drug in cancer prevention -- The LKB1:STRAD:MO25 complex -- Potential evolution of a pseudokinase -- LKB activation by STRAD and MO25 -- Location of LKB1 cancer mutations -- Activating protein kinases as a key challenge -- Analysis of the NUAK protein kinase -- Studying the role LKB1/NUAK1 signaling pathway in regulating cell adhesiveness and migration -- Modeling the novel LKB1.…”
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WNK1 pathway and its role in regulating hypertension

Table of Contents: “…Contents: Mutations in WNK kinases cause familial hypertension -- WNK1 interacts with and activates SPAK and OSR1 -- Physiological functions of SPAK and OSR1 -- Hyperosmotic conditions affect NKCC1 via WNK1 and SPAK/OSR1 -- A suggested mechanism of action for Thiazide diuretics in Gordon's syndrome patients -- How the WNK pathway regulates blood pressure-a current model -- Defining physiological roles of SPAK in knock-in mice -- MO25 also regulates the activity of SPAK/OSR1 -- Functions and schematic representation of LKB1 and SPAK/OSR1 protein complexes.…”
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Function and regulation of the PDK1 kinase

Table of Contents: “…Contents: The insulin cascade -- Approaches to study the insulin signalling pathway -- GSK3 regulation of glycogen synthase by insulin -- Inactivation of GSK3 by PI3K -- GSK3 inactivation by other kinases -- Protein Kinase B (Akt) -- PKB signal transduction -- Substrate specificity of PKB -- Activation of PKB by insulin -- Phosphorylation of PKB on Thr308 and Ser473 -- PKB phosphorylation on the catalytic domain -- How insulin locates PKB to the plasma membrane -- PKB translocation to the cell membrane -- Molecular mechanism of PKB activation -- Phosphorylation of PKB -- Discovery of PDK1 -- Primary structure of human PDK1 -- PIP3 requirement for PDK1 activation of PKB -- PDK1/2 phosphorylation of PKB -- The inability of PIP3 to activate PDK1 in vitro -- PKB in muscle-specific PDK1 knockout mice -- Glycogen synthase inactivation by GSK3 -- GSK3 & glycogen synthase in muscle-specific PDK1 knockout mice -- GSK3 knock-in mice -- Analysis of GSK3 isoforms in knock-in mice -- Glycogen synthase activity in knock-in mice -- Insulin effects mediated by protein kinases -- S6K, SGK and PKC activation -- PDK1 as a "master upstream kinase" -- S6K in muscle-specific PDK1 knockout mice -- PDK1 activation of 24 AGC kinase members -- Regulation of the PDK1 pathway -- The PDK1 kinase domain -- Defining the PIF-pocket by knock-in mutation -- S6K in PDK1 PIF-pocket knock-in mutation -- The role of PIP3 binding to the PH domain -- Inhibition of PKB in PDK1 PH domain knock-in cells -- The role of the PDK1 in cancer -- Evaluation of PDK1 as a drug target -- Generation of PDK1 hypomorphic mice -- PTEN and its effect in cancer -- PDK1 and PTEN in tumours.…”
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LKB1 pathway and its role in cancer

Table of Contents: “…Contents: Mutations in LKB1 kinase cause Peutz Jeghers cancer syndrome -- LKB1-activation and effects -- LKB1/AMPK signaling pathway inhibits mTOR -- Evaluating the role of LKB1 in regulating PTEN-induced tumourigenesis -- AMPK-activators-mechanisms of action -- AMPK-activators delay tumor onset in mice -- Metformin as a useful drug in cancer prevention -- The LKB1:STRAD:MO25 complex -- Potential evolution of a pseudokinase -- LKB activation by STRAD and MO25 -- Location of LKB1 cancer mutations -- Activating protein kinases as a key challenge -- Analysis of the NUAK protein kinase -- Studying the role LKB1/NUAK1 signaling pathway in regulating cell adhesiveness and migration -- Modeling the novel LKB1.…”
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WNK1 pathway and its role in regulating hypertension

Table of Contents: “…Contents: Mutations in WNK kinases cause familial hypertension -- WNK1 interacts with and activates SPAK and OSR1 -- Physiological functions of SPAK and OSR1 -- Hyperosmotic conditions affect NKCC1 via WNK1 and SPAK/OSR1 -- A suggested mechanism of action for Thiazide diuretics in Gordon's syndrome patients -- How the WNK pathway regulates blood pressure-a current model -- Defining physiological roles of SPAK in knock-in mice -- MO25 also regulates the activity of SPAK/OSR1 -- Functions and schematic representation of LKB1 and SPAK/OSR1 protein complexes.…”
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Function and regulation of the PDK1 kinase

Table of Contents: “…Contents: The insulin cascade -- Approaches to study the insulin signalling pathway -- GSK3 regulation of glycogen synthase by insulin -- Inactivation of GSK3 by PI3K -- GSK3 inactivation by other kinases -- Protein Kinase B (Akt) -- PKB signal transduction -- Substrate specificity of PKB -- Activation of PKB by insulin -- Phosphorylation of PKB on Thr308 and Ser473 -- PKB phosphorylation on the catalytic domain -- How insulin locates PKB to the plasma membrane -- PKB translocation to the cell membrane -- Molecular mechanism of PKB activation -- Phosphorylation of PKB -- Discovery of PDK1 -- Primary structure of human PDK1 -- PIP3 requirement for PDK1 activation of PKB -- PDK1/2 phosphorylation of PKB -- The inability of PIP3 to activate PDK1 in vitro -- PKB in muscle-specific PDK1 knockout mice -- Glycogen synthase inactivation by GSK3 -- GSK3 & glycogen synthase in muscle-specific PDK1 knockout mice -- GSK3 knock-in mice -- Analysis of GSK3 isoforms in knock-in mice -- Glycogen synthase activity in knock-in mice -- Insulin effects mediated by protein kinases -- S6K, SGK and PKC activation -- PDK1 as a "master upstream kinase" -- S6K in muscle-specific PDK1 knockout mice -- PDK1 activation of 24 AGC kinase members -- Regulation of the PDK1 pathway -- The PDK1 kinase domain -- Defining the PIF-pocket by knock-in mutation -- S6K in PDK1 PIF-pocket knock-in mutation -- The role of PIP3 binding to the PH domain -- Inhibition of PKB in PDK1 PH domain knock-in cells -- The role of the PDK1 in cancer -- Evaluation of PDK1 as a drug target -- Generation of PDK1 hypomorphic mice -- PTEN and its effect in cancer -- PDK1 and PTEN in tumours.…”
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Function and regulation of the PDK1 kinase

Table of Contents: “…Contents: The insulin cascade -- Approaches to study the insulin signalling pathway -- GSK3 regulation of glycogen synthase by insulin -- Inactivation of GSK3 by PI3K -- GSK3 inactivation by other kinases -- Protein Kinase B (Akt) -- PKB signal transduction -- Substrate specificity of PKB -- Activation of PKB by insulin -- Phosphorylation of PKB on Thr308 and Ser473 -- PKB phosphorylation on the catalytic domain -- How insulin locates PKB to the plasma membrane -- PKB translocation to the cell membrane -- Molecular mechanism of PKB activation -- Phosphorylation of PKB -- Discovery of PDK1 -- Primary structure of human PDK1 -- PIP3 requirement for PDK1 activation of PKB -- PDK1/2 phosphorylation of PKB -- The inability of PIP3 to activate PDK1 in vitro -- PKB in muscle-specific PDK1 knockout mice -- Glycogen synthase inactivation by GSK3 -- GSK3 & glycogen synthase in muscle-specific PDK1 knockout mice -- GSK3 knock-in mice -- Analysis of GSK3 isoforms in knock-in mice -- Glycogen synthase activity in knock-in mice -- Insulin effects mediated by protein kinases -- S6K, SGK and PKC activation -- PDK1 as a "master upstream kinase" -- S6K in muscle-specific PDK1 knockout mice -- PDK1 activation of 24 AGC kinase members -- Regulation of the PDK1 pathway -- The PDK1 kinase domain -- Defining the PIF-pocket by knock-in mutation -- S6K in PDK1 PIF-pocket knock-in mutation -- The role of PIP3 binding to the PH domain -- Inhibition of PKB in PDK1 PH domain knock-in cells -- The role of the PDK1 in cancer -- Evaluation of PDK1 as a drug target -- Generation of PDK1 hypomorphic mice -- PTEN and its effect in cancer -- PDK1 and PTEN in tumours.…”
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LKB1 pathway and its role in cancer

Table of Contents: “…Contents: Mutations in LKB1 kinase cause Peutz Jeghers cancer syndrome -- LKB1-activation and effects -- LKB1/AMPK signaling pathway inhibits mTOR -- Evaluating the role of LKB1 in regulating PTEN-induced tumourigenesis -- AMPK-activators-mechanisms of action -- AMPK-activators delay tumor onset in mice -- Metformin as a useful drug in cancer prevention -- The LKB1:STRAD:MO25 complex -- Potential evolution of a pseudokinase -- LKB activation by STRAD and MO25 -- Location of LKB1 cancer mutations -- Activating protein kinases as a key challenge -- Analysis of the NUAK protein kinase -- Studying the role LKB1/NUAK1 signaling pathway in regulating cell adhesiveness and migration -- Modeling the novel LKB1.…”
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WNK1 pathway and its role in regulating hypertension

Table of Contents: “…Contents: Mutations in WNK kinases cause familial hypertension -- WNK1 interacts with and activates SPAK and OSR1 -- Physiological functions of SPAK and OSR1 -- Hyperosmotic conditions affect NKCC1 via WNK1 and SPAK/OSR1 -- A suggested mechanism of action for Thiazide diuretics in Gordon's syndrome patients -- How the WNK pathway regulates blood pressure-a current model -- Defining physiological roles of SPAK in knock-in mice -- MO25 also regulates the activity of SPAK/OSR1 -- Functions and schematic representation of LKB1 and SPAK/OSR1 protein complexes.…”
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