Quantitative analysis of receptor allosterism and its implication for drug discovery

Quantitative analysis of receptor allosterism and its implication for drug discovery

Saved in:
Bibliographic Details
Other Authors: Zhang, Rumin (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2015.
Series:Henry Stewart talks. Biomedical & life sciences collection.
Subjects:
Cell receptors.
Drug development.
Drug receptors.
Pharmaceutical chemistry.
Drug Agonism.
Drug Discovery.
Receptors, Cytoplasmic and Nuclear.
Receptors, G-Protein-Coupled > agonists.
Receptors, G-Protein-Coupled > chemistry.
Online Access:https://hstalks.com/bs/3187/
Tags: Add Tag
No Tags, Be the first to tag this record!
Table of Contents:
  • Contents: G protein-coupled receptors (GPCRs)
  • Receptor agonism and allosterism
  • Orthosteric and allosteric binders
  • Inverse, partial and full agonists
  • Positive, silent and negative allosteric modulators (PAMs, SAMs and NAMs)
  • Allosteric two-state model and general operational model with constitutive receptor activity
  • Optimal design of experiment
  • Global curve fitting analysis of affinity and efficacy parameters
  • Beta supremacy
  • Monte Carlo simulations.

Similar Items