Quantitative analysis of receptor allosterism and its implication for drug discovery
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| Other Authors: | |
|---|---|
| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2015.
|
| Series: | Henry Stewart talks. Biomedical & life sciences collection.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/3187/ |
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| LEADER | 00000cgm a2200000 a 4500 | ||
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| 001 | HST4030 | ||
| 003 | UkLoHST | ||
| 006 | m c | ||
| 007 | cr|cna|||a|||| | ||
| 007 | vz|czazum | ||
| 008 | 160115s2015 enk|||||||||||s|||v|eng d | ||
| 028 | 5 | 0 | |a 4030 |b Henry Stewart Talks |
| 035 | |a (UkLoHST)3187 | ||
| 040 | |a UkLoHST |b eng |c UkLoHST | ||
| 100 | 1 | |a Zhang, Rumin, |u (Merck, USA) |4 spk |9 100103 | |
| 245 | 1 | 0 | |a Quantitative analysis of receptor allosterism and its implication for drug discovery |h [electronic resource] / |c Rumin Zhang. |
| 260 | |a London : |b Henry Stewart Talks, |c 2015. | ||
| 300 | |a 1 online resource (1 streaming video file (57 min.) : |b color, sound). | ||
| 490 | 1 | |a The biomedical & life sciences collection, |x 2056-452X | |
| 500 | |a Animated audio-visual presentation with synchronized narration. | ||
| 500 | |a Title from title frames. | ||
| 505 | 0 | |a Contents: G protein-coupled receptors (GPCRs) -- Receptor agonism and allosterism -- Orthosteric and allosteric binders -- Inverse, partial and full agonists -- Positive, silent and negative allosteric modulators (PAMs, SAMs and NAMs) -- Allosteric two-state model and general operational model with constitutive receptor activity -- Optimal design of experiment -- Global curve fitting analysis of affinity and efficacy parameters -- Beta supremacy -- Monte Carlo simulations. | |
| 506 | |a Access restricted to subscribers. | ||
| 538 | |a Mode of access: World Wide Web. | ||
| 650 | 0 | |a Cell receptors. |9 100104 | |
| 650 | 0 | |a Drug development. |9 100105 | |
| 650 | 0 | |a Drug receptors. |9 100106 | |
| 650 | 0 | |a Pharmaceutical chemistry. |9 100107 | |
| 650 | 2 | |a Drug Agonism. |9 100108 | |
| 650 | 2 | |a Drug Discovery. |9 100109 | |
| 650 | 2 | |a Receptors, Cytoplasmic and Nuclear. |9 100110 | |
| 650 | 2 | |a Receptors, G-Protein-Coupled |x agonists. |9 100111 | |
| 650 | 2 | |a Receptors, G-Protein-Coupled |x chemistry. |9 100112 | |
| 830 | 0 | |a Henry Stewart talks. |p Biomedical & life sciences collection. |9 100113 | |
| 856 | 4 | 0 | |u https://hstalks.com/bs/3187/ |
| 999 | |c 214808 |d 214807 | ||
G-Protein coupled receptors in drug discovery