Host genetic factors that limit HIV and AIDS

Host genetic factors that limit HIV and AIDS

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Bibliographic Details
Other Authors: Winkler, Cheryl A. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2013.
Series:Henry Stewart talks. Biomedical & life sciences collection.
Subjects:
AIDS (Disease) > Genetic aspects.
HIV infections.
Acquired Immunodeficiency Syndrome > genetics.
Acquired Immunodeficiency Syndrome > immunology.
Genome-Wide Association Study.
HIV Infections > genetics.
HIV Infections > immunology.
Online Access:https://hstalks.com/bs/2603/
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Table of Contents:
  • Contents: Overview of candidate gene association studies of HIV and AIDS
  • Key role for genetic variants involved in cell entry and host defenses
  • Homozygous CCR5 32 basepair deletion prevents HIV Infection
  • Acquired Immunity: HLA Class 1 proteins
  • Key mediators of HIV progression
  • Innate Protection: HLA and KIRS interactions in HIV disease
  • Overview of Genome Wide Association Studies (GWAS)
  • Overwhelming influence of HLA class I on HIV Progression and control of HIV viral load
  • Non-HLA genetic associations with extreme phenotypes
  • No new variants identified that prevent HIV infection
  • Discovery of chromosome 22 associations with HIV-associated nephropathy
  • Future studies
  • Epigenetic, proteomic, functional studies
  • Potential role of rare variants.

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