Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1
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| Other Authors: | |
|---|---|
| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2014.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Antivirals.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/2659/ Series |
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| 028 | 5 | 0 | |a 3250 |b Henry Stewart Talks |
| 035 | |a (UkLoHST)2659 | ||
| 040 | |a UkLoHST |b eng |c UkLoHST | ||
| 100 | 1 | |a Rossi, John, |u (Beckman Research Institute of the City of Hope, USA) |4 spk |9 104513 | |
| 245 | 1 | 0 | |a Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1 |h [electronic resource] / |c John Rossi. |
| 260 | |a London : |b Henry Stewart Talks, |c 2014. | ||
| 300 | |a 1 online resource (1 streaming video file (38 min.) : |b color, sound). | ||
| 490 | 1 | |a Antivirals : latest developments and future progress, |x 2056-452X | |
| 500 | |a Animated audio-visual presentation with synchronized narration. | ||
| 500 | |a Title from title frames. | ||
| 505 | 0 | |a Contents: Systemic RNA interference (RNAi): Therapeutics for the treatment of HIV-1 -- HIV life cycle -- Typical Course of HIV infection -- Why do we need new HIV drugs? -- Major goals of anti-HIV therapies -- Combinatorial RNA based therapy for HIV -- Applying RNAi for the treatment of human diseases -- treat HIV infection by systemic delivery of small RNAs -- Aptamers -- Chimeric-siRNA aptamer uptake into gp120 expressing cells -- Aptamer-targeted RNA interference for HIV-1 therapy -- Aptamer and aptamer chimera mediated inhibition of HIV-1 -- Small animal model for studying anti-HIV RNAi based therapies -- Both aptamer and aptamer chimera inhibit HIV infection -Aptamer and chimeric aptamer-siRNA prevent CD4+ cell decline -- Aptamer and dsiRNAS effect on viral load -- Flexible PAMAM dendrimers with a triethanolamine core -- Dendrimers plus siRNAs form nanoparticles, protect siRNA from degradation and deliver siRNAs to T-lymphocytes -- G5 dendrimer delivered siRNAs down regulate target mRNAs in vitro -- Multiplex siRNAs for HIV-1 treatment -- In vivo analyses of G5 dendrimer delivered siRNAs -- Reductions in HIV loads following dendrimer siRNA injections -- Dendrimer-siRNA complexes protect HIV infected RAG-hu mice from CD4 T cell loss -- Bio distribution of G5 dendrimer siRNAs. | |
| 506 | |a Access restricted to subscribers. | ||
| 538 | |a Mode of access: World Wide Web. | ||
| 650 | 0 | |a Antiviral agents. |9 104514 | |
| 650 | 0 | |a Gene therapy. |9 104515 | |
| 650 | 0 | |a HIV infections |x Treatment. |9 104516 | |
| 650 | 0 | |a Small interfering RNA |x Therapeutic use. |9 104517 | |
| 650 | 2 | |a Acquired Immunodeficiency Syndrome |x drug therapy. |9 104518 | |
| 650 | 2 | |a Anti-HIV Agents |x therapeutic use. |9 104519 | |
| 650 | 2 | |a Genetic Therapy. |9 104520 | |
| 650 | 2 | |a HIV Infections |x drug therapy. |9 104521 | |
| 650 | 2 | |a HIV-1 |x drug effects. |9 104522 | |
| 650 | 2 | |a Molecular Targeted Therapy. |9 104523 | |
| 650 | 2 | |a RNA Interference. |9 104524 | |
| 650 | 2 | |a RNA, Small Interfering |x therapeutic use. |9 104525 | |
| 830 | 0 | |a Henry Stewart talks. |p Biomedical & life sciences collection. |p Antivirals. |9 104526 | |
| 856 | 4 | 0 | |u https://hstalks.com/bs/2659/ |
| 856 | 4 | 2 | |u https://hstalks.com/bs/p/613/ |3 Series |
| 999 | |c 215130 |d 215129 | ||
Systemic RNA interference (RNAi) therapeutics for the treatment of HIV-1