Nucleosome assembly during DNA replication
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2009.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/1258/ Series |
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Table of Contents:
- Contents: Introduction to chromatin structure
- Primary function of chromatin: DNA compaction
- The nucleosome core particle
- De novo nucleosome assembly during the cell cycle
- Two distinct processes contribute to restoration of chromatin structure during DNA replication
- A fundamental problem in nucleosome assembly: histone-DNA aggregation
- Chromatin Assembly Factor 1 (CAF-1) and PCNA
- ASF1: a multi-talented histone chaperone
- Biomedical implications
- Agents that block the acetylation and deacetylation of new histones may sensitise cells to cancer chemotherapeutic agents
- Genome-wide histone acetylation, deacetylation and epigenetic inheritance
- Epigenetic xerox machines as potential targets for cancer therapy and regenerative medicine.
Initiation of DNA replication