The pRB/E2F pathway
Saved in:
| Other Authors: | |
|---|---|
| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2009.
|
| Series: | Henry Stewart talks. Biomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate.
|
| Subjects: | |
| Online Access: | https://hstalks.com/bs/1254/ Series |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Add Tag
Table of Contents:
- Contents: The E2F transcription factors control cell cycle entry
- The pRB/E2F pathway
- pRB and E2F are both families of proteins
- Differential roles of the pocket proteins
- Repression and activation of E2F target genes is regulated by distinct E2F complexes
- Rb mutant mice
- Inhibition of the activating E2Fs is key to pRB's tumor suppressive activity
- The activating E2Fs can also induce apoptosis and senescence genes in tumor cells
- Role of pRB-E2F in DNA damage response
- pRB contributes to the activation of pro-apoptotic genes in response to DNA damage.
Drug discovery and target validation in the p53 pathway