The spindle checkpoint

The spindle checkpoint

Saved in:
Bibliographic Details
Other Authors: Hardwick, Kevin G. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2009.
Series:Henry Stewart talks. Biomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate.
Subjects:
Cell Cycle.
Mitosis.
Online Access:https://hstalks.com/bs/1266/
Series
Tags: Add Tag
No Tags, Be the first to tag this record!
Table of Contents:
  • Contents: Cell cycle checkpoints
  • The metaphase to anaphase transition
  • The spindle checkpoint
  • What do cells monitor?
  • Unattached kinetochores
  • Lack of tension
  • Checkpoint components
  • Budding yeast genetic screens
  • Microcolony assay
  • Localisation of Mad proteins
  • Checkpoint proteins are all recruited kinetochores
  • Role of kinetochores
  • Global signaling
  • Identification of Cdc20 as the checkpoint effector
  • CdC20-APC
  • FRAP
  • Mad1/Mad2 complex as a template
  • The anaphase promoting complex (APC)
  • How is anaphase onset inhibited
  • Mad2 and Mad3 bind mitotic APC
  • Separase regulation by securin
  • Error correction
  • Chromosomal passenger proteins
  • How to sense a lack of tension?
  • Checkpoint role(s) of Aurora kinase (Ipl1)
  • Checkpoint silencing
  • Disease relevance
  • Future directions.

Similar Items