Global analysis of gene translation

Global analysis of gene translation

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Bibliographic Details
Other Authors: Tofilon, Philip J. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2009.
Series:Henry Stewart talks. Biomedical & life sciences collection. Microarrays : their design and use.
Subjects:
Gene Expression.
Microarray Analysis.
Oligonucleotide Array Sequence Analysis.
Protein Biosynthesis > radiation effects.
Online Access:https://hstalks.com/bs/1201/
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Table of Contents:
  • Contents: Radiation-induced gene expression has long been considered to play a role in determining cellular radioresponse
  • Analyses of single genes and whole genomes indicate that radiation-induced changes at the mRNA level do not correlate with changes in corresponding proteins
  • Microarray analysis of polysome-bound RNA indicates that radiation modifies the translational activity of mRNA subpopulations, which correlates with protein products
  • Gene translation is considerably more susceptible to radiation-induced changes than is the transcriptome
  • Defining the genes whose translation is modified by radiation may provide an approach for identifying critical proteins and pathways that serve as determinants of radiosensitivity.

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