Replication licensing

Replication licensing

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Bibliographic Details
Other Authors: Blow, J. Julian (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2009.
Series:Henry Stewart talks. Biomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate.
Subjects:
Cell Cycle.
Genes, cdc.
Licensure, Medical.
Online Access:https://hstalks.com/bs/1256/
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Table of Contents:
  • Contents: Problems in ensuring complete genome replication
  • Experiments revealing the existence of a replication licence
  • The licensing reaction
  • ORC, Cdc6, Cdt1 and Mcm2-7
  • Cell cycle regulation of licensing
  • Pre-RC substrates in yeast
  • Regulation of licensing in animal cells by Cdt1 degradation and geminin inhibition
  • Is there a licensing checkpoint?
  • Replication licensing and cancer
  • The "MCM paradox" and dormant replication origins
  • The licensing system as a potential anti-cancer target.

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