Predicting TSE transmission

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Bibliographic Details
Other Authors:	Manson, Jean (Speaker)
Format:	Electronic Video
Language:	English
Published:	London : Henry Stewart Talks, 2008.
Series:	Henry Stewart talks. Biomedical & life sciences collection. Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi.
Subjects:	Amyloid. Prions.
Online Access:	https://hstalks.com/bs/952/ Series
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Table of Contents:

Contents: The TSEs continue to pose a problem to animal and human health
The vCJD epidemic appears to be in decline but new risks of human to human transmission are now apparent
Chronic wasting disease is a major problem currently in the US although its presence has not yet been detected in Europe
Predicting and preventing transmission of disease requires an understanding of the routes of transmission within and between animals and the host factors which determine susceptibility
We have studied natural disease and both in vivo and in vitro model systems to unravel the basic mechanisms of disease
PrP protein has a central role in the outcome disease and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent
Precisely how host PrP influences the outcome of disease has not been established
Both mutations and glycosylation can profoundly influence transmission both within and between species.

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