Structural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G

Structural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G

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Bibliographic Details
Other Authors: Frank, J. (Joachim), 1940- (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2008.
Series:Henry Stewart talks. Biomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis.
Subjects:
Protein Biosynthesis.
Ribosomal Proteins.
Ribosomes.
Online Access:https://hstalks.com/bs/806/
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Table of Contents:
  • Contents: Schematic of elongation cycle
  • Role of elongation factors EF-G and EF-Tu
  • Molecular mimicry of elongation factors
  • Binding positions of factors and tRNA during elongation cycle
  • Process of tRNA selection
  • Proofreading
  • Role of bases A1492 and A1493
  • GTP hydrolysis on EF-Tu
  • tRNA as a molecular spring
  • Translocation
  • Intersubunit ratchet motion
  • Induced fit
  • FRET studies of ratchet motion
  • Hybrid states of tRNA
  • Role of GTP hydrolysis in translocation.

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