Oxidative stress in ALS

Oxidative stress in ALS

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Bibliographic Details
Other Authors: Shaw, Pamela J. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2007.
Series:Henry Stewart talks. Biomedical & life sciences collection. Free radicals and the oxygen paradox : oxidative stress in biology, aging and disease.
Subjects:
Free Radicals.
Oxidative Stress.
Online Access:https://hstalks.com/bs/395/
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Table of Contents:
  • Contents: Key facts
  • The normal human motor system
  • Motor neurone disease: clinical consequences
  • Spared motor neurone groups
  • Prognosis
  • Features of motor neurones which may underlie selective vulnerability
  • Complex and multifactorial disease
  • Genetic factors
  • SOD1 mutations
  • Potential mechanisms of neuronal oxidative stress
  • Sources of intracellular oxidative stress
  • Mitochondrial free radical production
  • ROS
  • Evidence for the role of oxidative stress in ALS
  • NSC34 cell model
  • G93A mutant SOD1
  • Oxidative stress in human ALS
  • Major pathogenetic factors
  • Glutamate
  • Excitotoxicity
  • Mitochondrial dysfunction
  • Potential mechanisms of action of antioxidant drugs
  • Clinical trials.

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