Whole-genome association studies practical advice and considerations /

Whole-genome association studies practical advice and considerations /

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Bibliographic Details
Other Authors: Weale, Mike (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2007.
Series:Henry Stewart talks. Biomedical & life sciences collection. Genetic epidemiology II : latest developments.
Subjects:
Genetic Predisposition to Disease > epidemiology.
Online Access:https://hstalks.com/bs/611/
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Table of Contents:
  • Contents: What are whole-genome (genome-wide) association studies and why do them?
  • Steps in WGA study
  • HIV setpoint
  • Phenotype definition
  • Setpoint
  • Whole genome genotyping panels
  • PLINK
  • Cryptic population stratification
  • PCA and EIGENSTRAT
  • SNP-by-SNP analysis
  • Multiple testing approaches
  • Bonferroni method
  • Q-Q (quantile-quantile) plot
  • False discovery rate
  • Permutation
  • Outright hits
  • Pool of hits
  • Bayesian alternatives
  • Bayes factor
  • Bayesian false discovery probability (BFDP).

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