HIV preintegration complexes

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Bibliographic Details
Other Authors: Ratner, Lee (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2007.
Series:Henry Stewart talks. Biomedical & life sciences collection. Retroviruses : biology, pathogenic mechanisms and treatment.
Subjects:
Online Access:https://hstalks.com/bs/509/
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Table of Contents:
  • Contents: Role of cell cycle progression in retrovirus replication
  • Resting T-cells and HIV
  • Uncoating and PIC nuclear import
  • Preintegration complex (PIC)
  • Intracellular transport of PIC
  • HIV-1 Vpr vs. HIV-2 Vpx
  • HIV-1 Vpr interaction factors
  • HIV-2: model system for PIC nuclear import
  • Vpx cellular localization
  • Ability of Vpx-NLS mutant viruses to infect arrested and dividing U937 cells
  • Nuclear localization signal of HIV-2 Vpx
  • Vpx interaction with HSP 40
  • Heat shock proteins and viruses
  • Over-expression of DNAJB6 causes reduction of Vpx packaging in VLP
  • Down regulation of DNAJB6 reduces nuclear import of HIV-2 PIC
  • Novel mechanism of Vpx-mediated PIC import.