Protein oxidation and removal of oxidized proteins by proteolysis

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Bibliographic Details
Other Authors: Grune, Tilman (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2007.
Series:Henry Stewart talks. Biomedical & life sciences collection. Free radicals and the oxygen paradox : oxidative stress in biology, aging and disease.
Subjects:
Online Access:https://hstalks.com/bs/383/
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Table of Contents:
  • Contents: Oxidized proteins
  • Intracellular proteases
  • The 20S core proteasome
  • Proteasomal particles
  • The proteasome-ubiquitin system
  • Protein oxidation and proteasome
  • Degradation of oxidized proteins and protein function
  • Protein surface hydrophobicity
  • Unfolding of oxidized proteins
  • Stability of the 20S proteasome towards oxidation
  • Oxidative stress and protein turnover
  • Oxidation-induced proteolysis
  • Degradation of oxidized proteins in cells
  • What happens if degradation fails?
  • Protein aggregates inhibit the proteasome
  • Particle uptake by fibroblasts